PH-797804

Alternative_name

PH-797804; PH797804; PH 797804; 3-[3-bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide; 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide
Description

PH-797804 is a novel pyridinone inhibitor of p38α with IC50 of 26 nM; 4-fold more selective versus p38β.
CAS Number

586379-66-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₂H₁₉BrF₂N₂O₃
Molecular Weight

477.3
Cell Permeable

Yes
Purity

>98%
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent and selective P38 MAPK inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD18251426
PubChem CID

22049997
PubChem CID Link
SMILES

CC1=C(C=C(C=C1)C(=O)NC)N2C(=CC(=C(C2=O)Br)OCC3=C(C=C(C=C3)F)F)C
InChi

InChI=1S/C22H19BrF2N2O3/c1-12-4-5-14(21(28)26-3)9-18(12)27-13(2)8-19(20(23)22(27)29)30-11-15-6-7-16(24)10-17(15)25/h4-10H,11H2,1-3H3,(H,26,28)
InChi Key

KCAJXIDMCNPGHZ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:11217
Gene

SPAM1
Long gene name

sperm adhesion molecule 1
Synonyms gene name
- sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
Synonyms
- HYAL5
- PH-20
- SPAG15
Synonyms name
- PH-20 hyaluronidase
GenBank acession
- L13781
Locus

7q31
Discovery year

1995-07-18
Pubmed identfication
- 8282124
- 8575780
Classification
- Hyaluronidases
VEGA ID

OTTHUMG00000157284

Identity

HGNC:187
Gene

ADAM1A
Long gene name

ADAM metallopeptidase domain 1A (pseudogene)
Synonyms gene
- ADAM1
Synonyms gene name
- a disintegrin and metalloproteinase domain 1 (fertilin alpha) pseudogene
- ADAM metallopeptidase domain 1, pseudogene
- ADAM metallopeptidase domain 1A, pseudogene
Synonyms
- FTNAP
- PH-30a
- Ftna
- ADAM1P
Synonyms name
- fertilin alpha
GenBank acession
- Y09232
Locus

12q24.12-q24.13
Discovery year

1998-12-01
Entrez gene record

8759
Pubmed identfication
- 9032439
RefSeq identity
- NG_001216
Classification
- ADAM metallopeptidase domain containing
VEGA ID

OTTHUMG00000154247

Identity

HGNC:28858
Gene

P4HTM
Long gene name

prolyl 4-hydroxylase, transmembrane
Synonyms gene name
- prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms
- P4H-TM
- PHD4
- PH4
- HIFPH4
- FLJ20262
- EGLN4
- PH-4
Synonyms name
- Prolyl hydroxlase domain-containing 4
- hypoxia inducible factor prolyl 4 hydroxylase
Locus

3p21.31
Discovery year

2008-12-08
Entrez gene record

54681
Pubmed identfication
- 12163023
- 17726031
RefSeq identity
- NM_177938
VEGA ID

OTTHUMG00000074057