SMI-4a
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Catalog number2211-5
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PricePlease ask
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Size5 mg
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Alternative_name5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
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DescriptionA selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines.
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CAS Number327033-36-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₁H₆F₃NO₂S
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Molecular Weight273.23
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO (>10 mg/ml)
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HandlingProtect from air and light
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Tag LineA pim kinase inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24months
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MDL NumberMFCD01152003
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PubChem CID1361334
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SMILESC1=CC(=CC(=C1)C(F)(F)F)C=C2C(=O)NC(=O)S2
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InChiInChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5-
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InChi KeyNGJLOFCOEOHFKQ-YVMONPNESA-N
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MSDS AvailableYes
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Gene target
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Short nameSMI-4a
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Alternative nameSMI-4a
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