Caspase 8, Cleavage Site (Asp384) (FLICE, MASH, Mch5)
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Catalog number
GEN601687
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Price
Please ask
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Size
100ul
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Also known as
Caspase 8, Cleavage Site
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Other names
caspase 8; Caspase-8; caspase-8; FADD-like ICE; OTTHUMP00000163717; OTTHUMP00000163720; OTTHUMP00000165062; OTTHUMP00000165063; OTTHUMP00000165064; OTTHUMP00000206552; MACH-alpha-1/2/3 protein; apoptotic protease Mch-5; MACH-beta-1/2/3/4 protein; apoptotic cysteine protease; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; FADD-homologous ICE/CED-3-like protease; caspase 8, apoptosis-related cysteine protease; caspase 8, apoptosis-related cysteine peptidase; Apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; FLICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog
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Category
Antibodies
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Subcategory
Mnoclonal antibodies
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Gene name
CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
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Gene name synonims
CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
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Other gene names
CASP8; CASP8; CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; FLJ17672; MGC78473; MCH5
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Clonality
Monoclonal
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Immunoglobulin isotype
IgG1
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Clone
3A52
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Host organism
Mouse (Mus musculus)
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Source organism
Human (Homo sapiens)
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Species reactivity
Human (Homo sapiens); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivity
Detects endogenous levels of the small subunit of caspase-8 resulting from cleavage at Asp384. Does not crossreact with full length caspase-8.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification method
Affinity Purified by immunoaffinity chromatography.
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Form Appearance
Supplied as a liquid in 10mM HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol, 0.02% sodium azide.
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Concentration
N/A
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Storage and shipping
Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage, For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested applications
ELISA (EL/EIA), Western Blot (WB)
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Description
Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
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Gene target
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Gene symbol
CASP10, CASP8, CFLAR
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Short name
Caspase 8, Cleavage Site (Asp384) (FLICE, MASH, Mch5)
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Alternative name
Anti-Caspase 8, Cleavage Site (Asp384) (FLICE, MASH, Mch5)
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Gene info
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Identity
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Gene
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Long gene name
caspase 10
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Synonyms gene name
- caspase 10, apoptosis-related cysteine protease
- caspase 10, apoptosis-related cysteine peptidase
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
1997-04-21
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Caspases
- Death effector domain containing
- Death inducing signaling complex
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene name
caspase 8
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Synonyms gene name
- caspase 8, apoptosis-related cysteine protease
- caspase 8, apoptosis-related cysteine peptidase
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Synonyms
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GenBank acession
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Locus
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Discovery year
1996-11-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Caspases
- Death effector domain containing
- Death inducing signaling complex
- Ripoptosome
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VEGA ID
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Locus Specific Databases
Gene info
MeSH Data
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Name
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Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
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