Anti-FGFR3 Antibody

• Catalog number
  A1630-100
• Price
  Please ask
• Size
  100 µl

• Antibody Target
  FGFR3
• Target Alternative Name
  JTK4; Fibroblast growth factor receptor 3; FGFR-3; CD333
• Antibody Type
  Polyclonal
• Species Reactivities
  Human, Mouse, Rat
• Immunogen Sequence
  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human FGFR3
• Accession
  P22607
• Gene Id
  2261
• Appearance
  Colorless liquid
• Form
  Liquid
• Concentration
  1 mg/ml
• Formulation
  In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide
• Purification
  Affinity purified
• Application
  WB, IHC
• Positive Control
  WB: HeLa; A549; T47D; mouse kidney; mouse heart; rat lung whole cell lysates, IHC: human breast cancer
• Application And Usages
  WB; 1:500 – 1:1000, IHC; 1:100 – 1:200
• Description
  Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  FGFR3  
• Gene symbol
  FGFR3
• Short name
  Anti-FGFR3 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibody toFGFR3 (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:3690
• Gene
  FGFR3
• Long gene name
  fibroblast growth factor receptor 3
• Synonyms gene
  • ACH
• Synonyms gene name
  • achondroplasia, thanatophoric dwarfism
• Synonyms
  • CEK2
  • JTK4
  • CD333
• GenBank acession
  • M64347
• Locus
  4p16.3
• Discovery year
  1991-06-07
• Entrez gene record
  2261
• Pubmed identfication
  • 1847508
• RefSeq identity
  • NM_000142
• Classification
  • I-set domain containing
  • Receptor tyrosine kinases
  • CD molecules
• VEGA ID
  OTTHUMG00000121148
• Locus Specific Databases
  • LRG_1021

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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