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Measuring Cylinder

Measuring Cylinder is available 4 times from Abm miscellaneous labs

Q5012 | Measuring Cylinder 1000ul size: 1 Cylinder | 72.07 USD

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Q5011 | Measuring Cylinder 2000ul size: 1 Cylinder | 76.57 USD

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Q5010 | Measuring Cylinder 5000ul size: 1 Cylinder | 127.25 USD

Catalog number Q5010
Price127.25 USD
Size 1 Cylinder
Ordering If you wish to order Measuring Cylinder 5000ul, please use the catalogue number #Q5010
Short name Measuring Cylinder 5000ul
Alternative name Measuring Cylinder 5000ul
Additional information
PubMedThe activity of SCF-FBXW5 is negatively regulated by Polo-like kinase 4 (PLK4), which phosphorylates FBXW5 at Ser 151 to suppress its ability to ubiquitylate HsSAS-6.
Regulated HsSAS-6 levels normally ensure that each centriole seeds the formation of a single procentriole per cell cycle, thus playing a fundamental role in driving the centrosome duplication cycle and ensuring genome integrity.
Data show that depletion of hSAS-6 specifically inhibits the formation of CPAP-induced PLSs derived from procentrioles.
hSAS6 depletion hindered STIL targeting to the procentriole, implying that STIL and hSAS6 are mutually dependent for their centriolar localization.
Authors propose that CEP135 directly connects the central hub protein, hSAS-6, to the outer microtubules, and suggest that this interaction stabilizes the proper cartwheel structure for further CPAP-mediated centriole elongation.
HsSAS-6 homodimers are targeted to centrosomes where the local environment and high concentration of HsSAS-6 promote oligomerization, thus initiating procentriole formation.
A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.
Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC and is associated with a poor prognosis among patients with colon cancer.
SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.
expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.
Gene ontology - Biological processcentrosome duplication
centriole replication
Gene ontology - Molecular functionprotein binding

Q5013 | Measuring Cylinder 500ul size: 1 Cylinder | 66.44 USD

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Availability Please contact our specialists every day to check the availability and to request a quote.
Notes Designed for Research Use Only. Assembled in Canada.
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