LY-2109761

Alternative_name

4-(2-((4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-yl)oxy)ethyl)morpholine
Description

LY-2109761 is a highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor with Ki of 38 nM and 300 nM respectively. It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where it completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.
CAS Number

700874-71-1
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₇N₅O₂
Molecular Weight

441.52
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>30 mg/ml)
Handling

Protect from air and light
Tag Line

A highly potent and selective TGFβ receptor type I and type II (TβRI/II) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

11655119
PubChem CID Link
SMILES

C1CC2=C(C(=NN2C1)C3=CC=CC=N3)C4=C5C=CC(=CC5=NC=C4)OCCN6CCOCC6
InChi

InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
InChi Key

IHLVSLOZUHKNMQ-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes