Anti-alpha 5 beta 1 Integrin (Volociximab), Human IgG4 Antibody

• Catalog number
  A1092-200
• Price
  Please ask
• Size
  200 µg

• Antibody Target
  ITGA5
• Target Alternative Name
  Fibronectin receptor; CD49 antigen-like family member E; Integrin alpha-F; VLA-5; CD49e
• Antibody Type
  Monoclonal
• Clone
  M200
• Species Reactivities
  Human
• Immunogen Sequence
  Heterodimeric α5β1Fc fusion protein
• Accession
  P08648
• Gene Id
  3678
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300
• Purification
  Affinity purified using protein A
• Application
  ELISA; FC; IF; Block; IHC
• Description
  The antibody binds specifically to a5ß1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The a5ß1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Not Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  The Anti-alpha 5 beta 1 Integrin (Volociximab), IgG4 Antibody is a α- or alpha protein sometimes glycoprotein present in blood. This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• French translation
  anticorps

• Gene target
  alpha   beta   Integrin   Volociximab   IgG4  
• Short name
  Anti-alpha 5 beta 1 Integrin (Volociximab), IgG4 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Human IgG4, kappa
• Species
  Human, Humans
• Alternative name
  Antibody toa 5 b 1 Integrin (Volociximab), H. sapiens IgG4 (antibody to-)
• Alternative technique
  antibodies

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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