YC-1

Alternative_name

3-(5'-Hydroxymethyl-2'-furyl)-1-benzylindazole
Description

Cell-permeable. A nitric oxide (NO) independent, superoxide-sensitive soluble guanylyl cyclase (sGC) activator (EC₅₀ = 18 µM). Induces concentration-dependent increase in cGMP levels in cultured cells and in rabbit aortic rings. Inhibits platelet adhesion to collagen. A non-specific phosphodiesterase (PDE) inhibitor. YC-1 also inhibits HIF-α activity in tumors resulting in blocked angiogenesis and an inhibition of tumor growth. Inhibits Na⁺ channel.
CAS Number

170632-47-0
Structure Available

Yes
Molecular Formula

C₁₉H₁₆N₂O₂
Molecular Weight

304.34
Cell Permeable

Yes
Purity

≥98% by NMR
Solubilities

DMSO (100 mM) or EtOH (50 mM)
Handling

Protect from air and light
Tag Line

A soluble guanylyl cyclase (sGC) activator
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD06407798
PubChem CID

5712
PubChem CID Link
SMILES

C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
InChi

InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20- 19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
InChi Key

OQQVFCKUDYMWGV-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

YC-1
Gene symbol

NFYC, RBMS1, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR1289-1, MIR101-1, MIR16-1
Short name

YC-1
Alternative name

YC-1

Identity

HGNC:9907
Gene

RBMS1
Long gene name

RNA binding motif single stranded interacting protein 1
Synonyms gene
- C2orf12
Synonyms gene name
- chromosome 2 open reading frame 12
Synonyms
- SCR2
- MSSP-1
- MSSP-2
- MSSP-3
- YC1
- HCC-4
- DKFZp564H0764
Synonyms name
- suppressor of cdc 2 (cdc13) with RNA binding motif 2
- c-myc gene single strand binding protein 2
GenBank acession
- D28482
Locus

2q24.2
Discovery year

1998-02-27
Entrez gene record

5937
Pubmed identfication
- 8041632
- 8134115
- 7838710
RefSeq identity
- NM_016836
Classification
- RNA binding motif containing
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000132031

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081