SB-525334

• Catalog number
  2880-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
• Description
  SB-525334 is a potent and selective inhibitor of transforming growth factor-β receptor I (ALK5, TGF-βRI) (IC₅₀ = 14.3 nM); displays 4-fold less potency against ALK4 (IC₅₀ = 58.5 nM) and inactive as an inhibitor of ALK2, ALK3, and ALK6 (IC₅₀ > 10,000 nM). In cell-based assays, SB-525334 (1 µM) blocks TGF-β1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGF-β1-induced increases in plasminogen activator inhibitor-1 (PAI-1) and procollagen α1(I) mRNA expression in A498 renal epithelial carcinoma cells.
• CAS Number
  356559-20-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₁N₅
• Molecular Weight
  343.42
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective ALK5 inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD11045307
• PubChem CID
  9967941
• PubChem CID Link
• SMILES
  CC1=CC=CC(=N1)C2=C(N=C(N2)C(C)(C)C)C3=CC4=NC=CN=C4C=C3
• InChi
  InChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
• InChi Key
  DKPQHFZUICCZHF-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  SB-525334  
• Short name
  SB-525334
• Alternative name
  SB-525334

Product images

Similar products