Remodelin

• Catalog number
  9411-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  4-​[2-​(2-​cyclopentylidenehydrazinyl)-​4-​thiazolyl]-​benzonitrile
• Description
  Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells.
• CAS Number
  949912-58-7
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₄N₄S
• Molecular Weight
  282.36
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 15 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A N-acetyltransferase 10 (NAT10) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  44442376
• PubChem CID Link
• SMILES
  C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1
• InChi
  InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)
• InChi Key
  XAEJIFARBQJLML-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Remodelin  
• Short name
  Remodelin
• Alternative name
  Remodelin

MeSH Data

• Name
  Models, Animal
• Concept
  Scope note: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
• Tree numbers
  • E05.598

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