Human CellExp™ LAG3 / CD223, Fc Tag, human recombinant
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Catalog numberP1149-50
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Price:
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Size50 ug
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SynonymsLAG3, CD223, FDC
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Alternative_namesLAG3, CD223, FDC
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DescriptionA protein involved in lymphocyte activation
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RecombinantYes
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SourceHEK 293 cells
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Purity by SDS PAGE> 95%
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AssaySDS-PAGE
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Endotoxin Level< 1.0 EU per/ug
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Activity Specifications test methodMeasured by its binding ability in a functional ELISA.
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Biological activityImmobilized Human LAG-3, Fc Tag at 2ug/mL (100 uL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.
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Binding CapacityImmobilized Human LAG-3, Fc Tag at 2ug/mL (100 uL/well) can bind Anti-LAG3 MAb, Human IgG1 with a linear range of 0.1-2 ng/mL.
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Molecular Weight72.3 kDa
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Storage Temp-20°C
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ShippingGel Pack
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Shelf Life12 months
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AppearanceLyophilized
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Physical form descriptionLyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
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Reconstitution InstructionsReconstitute in sterile deionized water to the desired protein concentration.
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Background InformationLymphocyte activation gene 3 protein (LAG3) is also known as CD antigen CD223 and protein FDC, which belongs to immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. LAG3 /CD223 involved in lymphocyte activation. LAG3 /CD223 binds to HLA class-II antigens.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolLAG3
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Short nameCellExp™ LAG3 / CD223, Fc Tag, recombinant
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TechniqueRecombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelFc Tag
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ lymphocyte-activation gene 3 / CD223, fragment c detection labelled, H. sapiens Rec.
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Alternative techniquerec
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Alternative to gene targetlymphocyte-activation gene 3, CD223, LAG3 and IDBG-14994 and ENSG00000089692 and 3902, MHC class II protein binding, Cell surfaces, Lag3 and IDBG-188462 and ENSMUSG00000030124 and 16768, BT.18959 and IDBG-640276 and ENSBTAG00000034295 and 515155
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Gene info
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Identity
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Gene
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Long gene namelymphocyte activating 3
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Synonyms gene name
- lymphocyte-activation gene 3
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Synonyms
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Locus
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Discovery year1991-06-03
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Entrez gene record
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RefSeq identity
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Classification
- Immunoglobulin like domain containing
- CD molecules
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data