Anti-BRCA1 Antibody (BRCA1/1398)

• Catalog number
  A1448-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  BRCA1
• Target Alternative Name
  BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53
• Antibody Type
  Monoclonal
• Clone
  BRCA1/1398
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant human BRCA1 protein fragment (aa445-620)
• Accession
  P38398
• Gene Id
  672
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 10 mM PBS with 0.05% BSA & 0.05% azide
• Purification
  Protein A/G purification
• Application
  FC, IF, IHC
• Positive Control
  IHC: human Breast Carcinoma
• Application And Usages
  FC: 0.5-1 ug/1X106 cells, IF: 1-2 ug/ml, IHC: 5-10 ug/ml
• Description
  This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans.
• Handling
  The antibody solution should be gently mixed before use.
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BRCA1   BRCA1/1398  
• Gene symbol
  BRCA1, BRCA1P1
• Short name
  Anti-BRCA1 Antibody (BRCA1/1398)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse IgG1, kappa
• Alternative name
  Antibody toBRCA1 (antibody to-) (breast cancer 1, early onset/1398)
• Alternative technique
  antibodies
• Alternative to gene target
  breast cancer 1, early onset, BRCAI and BRCC1 and BROVCA1 and IRIS and PNCA4 and PPP1R53 and PSCP and RNF53, BRCA1 and IDBG-52172 and ENSG00000012048 and 672, androgen receptor binding, nuclei, Brca1 and IDBG-212218 and ENSMUSG00000017146 and 12189, BRCA1 and IDBG-640630 and ENSBTAG00000022520 and 353120

Gene info

• Identity
  HGNC:1100
• Gene
  BRCA1
• Long gene name
  BRCA1 DNA repair associated
• Synonyms gene name
  • breast cancer 1, early onset
  • breast cancer 1
• Synonyms
  • RNF53
  • BRCC1
  • PPP1R53
  • FANCS
• Synonyms name
  • BRCA1/BRCA2-containing complex, subunit 1
  • protein phosphatase 1, regulatory subunit 53
  • Fanconi anemia, complementation group S
• GenBank acession
  • U14680
• Locus
  17q21.31
• Discovery year
  1991-02-20
• Entrez gene record
  672
• Pubmed identfication
  • 1676470
  • 25472942
• RefSeq identity
  • NM_007294
• Classification
  • Ring finger proteins
  • Protein phosphatase 1 regulatory subunits
  • BRCA1 A complex
  • BRCA1 B complex
  • BRCA1 C complex
  • FA complementation groups
• VEGA ID
  OTTHUMG00000157426
• Locus Specific Databases
  • Breast Cancer
  • Fanconi Anaemia Mutation Database
  • BRCA1 database at LOVD-China
  • Global Variome shared LOVD
  • LOVD - Leiden Open Variation Database
  • LRG_292

Gene info

• Identity
  HGNC:28470
• Gene
  BRCA1P1
• Long gene name
  BRCA1 pseudogene 1
• Synonyms
  • LBRCA1
  • PsiBRCA1
  • pseudo-BRCA1
• Synonyms name
  • like-BRCA1
• Locus
  17q21.31
• Discovery year
  2005-05-26
• Entrez gene record
  394269
• Pubmed identfication
  • 11880951
  • 8954804
  • 10205276
• RefSeq identity
  • NG_003183

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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