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FYN (1302CT390.118.237) Monoclonal Antibody

FYN (1302CT390.118.237) Monoclonal Antibody is available 1 time from Bioss primary unconjugated antibodies labs

bsm-51263M | FYN (1302CT390.118.237) Monoclonal Antibody size: 0.1ml | 233.39 USD

Catalog number bsm-51263M
Price 233.39 USD
Size 0.1ml
1. Gene info
Identity4037
GeneFYN
Synonyms gene name
  • FYN oncogene related to SRC, FGR, YES
GenBank acession
Locus6q21
Discovery year1988-08-19
Pubmed identfication
Havana BLAST/BLATOTTHUMG00000016305
MeSH Data
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    Paraformaldehyde-fixed, paraffin embedded Human tonsil tissue; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 15 minutes; Blocking buffer (3% BSA) at room temperature for 30min; Antibody incubation with FYN (1302CT390.118.237) Monoclonal Antibody (bsm-51263M) at 1:25 for 1 hour at 37°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining.#.png
Product files
Long name FYN (1302CT390.118.237) Monoclonal Antibody
Also known as FYN (1302CT390.118.237) Monoclonal Antibody
Category Primary Antibodies
Conjugation Unconjugated
Target Antigen FYN
Specificity This is a highly specific antibody against FYN.
Modification(s) None
Modification site(s) Unmodified antibody
Clonality Monoclonal
Clone number 1302CT390.118.237
Source This FYN antibody is generated from a mouse immunized with a recombinant preotein from human FYN.
Gene ID number 2534
Swiss Prot P06241
Tested Applications WB, FCM, IHC-P
Recommended dilutions FC(1:25), IHC-P(1:25)
Cross reactivity Human
Cross reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the target antigen Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
Storage conditions Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
Synonym names SLK; SYN; p59-FYN; Tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; FYN
Properties If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
About Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
French translation anticorps
Gene targetFYN 1302CT390.118.237 Monoclonal
Short name FYN (1302CT390.118.237) Monoclonal Antibody
Technique Antibody
Alternative name FYN oncogene related to v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian), FGR, YES (1302CT390.118.237) monoclonal (Antibody to)
Alternative technique antibodies
Alternative to gene target FYN oncogene related to SRC, FGR, YES, p59-FYN and SLK and SYN, FYN and IDBG-95463 and ENSG00000010810 and 102724705,2534, transferase activity, nuclei, Fyn and IDBG-144629 and ENSMUSG00000019843 and 14360, FYN and IDBG-631420 and ENSBTAG00000011851 and 527263
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FYN (1302CT390.118.237) Monoclonal Antibody size: 0.1ml
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EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • FYN
  • 1302CT390.118.237
  • Monoclonal
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