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Alternative_name
N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
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Description
A potent, selective and ATP-competitive Met kinase superfamily inhibitor (IC₅₀ = 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM for c-Met, Axl, RON, and Tyro-3, respectively). it was >40-fold selective for Met kinase family targets versus Lck, VEGFR-2, and TrkA/B and > 500-fold selective versus all other receptor and non-receptor kinases.
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CAS Number
1025720-94-8
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₅H₁₉ClF₂N₄O₄
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Molecular Weight
512.89
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (>40 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent Met kinase superfamily inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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PubChem CID
24794418
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SMILES
CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F
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InChi
InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33)
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InChi Key
VNBRGSXVFBYQNN-UHFFFAOYSA-N
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MSDS Available
Yes
