Recombinant Human Natural Killer Cell Receptor 2B4/SLAMF4/CD244 Protein(C-6His) 50µg

• Catalog number
  PKSH032784-50µg
• Price
  Please ask
• Size
  50µg

• Synonym
  Natural killer cell receptor 2B4; NK cell activation-inducing ligand; NAIL; NKR2B4; h2B4; SLAM family member 4; SLAMF4; CD244; 2B4
• Activity
  NA
• Sequence
  Cys22-Arg221
• Fusion tag
  C-6His
• Accession
  Q9BZW8-2
• Expressed Host
  Human cells
• Shipping
  The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
• Purity
  ＞95% as determined by reducing SDS-PAGE.
• Endotoxin
  ＜1.0 EU per µg as determined by LAL test.
• Stability and Storage
  Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months
• Mol Mass
  23.1 kDa
• AP Mol Mass
  35-60 kDa
• Formulation
  Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
• Reconstitution
  Please refer to it for detailed information.
• Background
  Natural killer cell receptor 2B4 is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family.2B4 interacts with CD48, while other SLAM family proteins interact homophilically. Three additional splice variants of human 2B4 have deletions of the short region between the Ig-like domains, the second Ig-like domain, or a portion of the cytoplasmic tail.2B4 is expressed on all NK cells, γδ T cells, monocytes, some CD4+ and CD8+ T cells, and some dendritic cells. CD48 mediates 2B4+ cell interactions with nearly all hematopoietic cell types, including cells of the same type. 2B4/CD48 signaling cooperates with other receptor systems to either promote or inhibit NK and CD8+ T cell activation. The inhibitory activities are distinct from those of MHC I restricted inhibitory NK cell receptors. Ligation of 2B4 with antibodies or CD48 constructs can either directly trigger inhibitory signaling or disrupt an inhibitory interaction, leading to cellular activation. The inhibitory effect is associated with the long form of 2B4, while the activation is associated with the short form. 2B4 can also induce signaling through CD48.
• Product URL
• PDF URL
• Description
  For cells, cell lines and tissues in culture till half confluency. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  Natural   Killer   Receptor   2B4/SLAMF4/CD244   Protein   C-6His   50µg  
• Gene symbol
  CD244, GSTT1-AS1
• Short name
  Recombinant Natural Killer Receptor 2B4/SLAMF4/CD244 Protein(C-6His) 50µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Natural Killer cellular Receptor 2B4/SLAMF4/CD244 molecule, natural killer cellular receptor 2B4 Protein(C-6His) 50µg
• Alternative technique
  rec
• Alternative to gene target
  CD244 molecule, natural killer cell receptor 2B4, CD244 and IDBG-104114 and ENSG00000122223 and 51744, protein binding, Cell surfaces, Cd244 and IDBG-204694 and ENSMUSG00000004709 and 18106, CD244 and IDBG-630400 and ENSBTAG00000002951 and 513468
• Tissue
  cell

Gene info

• Identity
  HGNC:18171
• Gene
  CD244
• Long gene name
  CD244 molecule
• Synonyms gene name
  • natural killer cell receptor 2B4
  • CD244 natural killer cell receptor 2B4
  • CD244 molecule, natural killer cell receptor 2B4
• Synonyms
  • 2B4
  • NAIL
  • NKR2B4
  • Nmrk
  • SLAMF4
• GenBank acession
  • AF105261
• Locus
  1q23.3
• Discovery year
  2003-10-23
• Entrez gene record
  51744
• Pubmed identfication
  • 3772297
  • 10458320
• RefSeq identity
  • NM_016382
• Classification
  • Ig-like cell adhesion molecule family
  • Immunoglobulin like domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000028606

Gene info

• Identity
  HGNC:51839
• Gene
  GSTT1-AS1
• Long gene name
  GSTT1 antisense RNA 1
• Synonyms
  • lncRNA-AS-GSTT1(1-72)
  • lncRNA-CD244
  • lncRNA-BC050410
• GenBank acession
  • KI270879
  • BC050410
• Locus
  22q11.23 alternate reference locus
• Discovery year
  2015-08-05
• Entrez gene record
  106099130
• Pubmed identfication
  • 26150504
• RefSeq identity
  • NR_132348
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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