Brefeldin A

Alternative_name

Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone
Description

Brefeldin A has been shown to induce apoptosis in human tumor cells through caspase activation. It has also been shown to block translocation of proteins from the endoplasmic reticulum to the Golgi apparatus.
CAS Number

20350-15-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₆H₂₄O₄
Molecular Weight

280.36
Cell Permeable

Yes
Purity

≥99%
Solubilities

DMSO or EtOH (10 mg/ml)
Handling

Protect from light and moisture
Tag Line

Disruptor of Golgi apparatus
Storage Condition

-20°C
Shipping Condition

RT
Shelf Life

24months
MDL Number

MFCD12913297
PubChem CID

2430
PubChem CID Link
SMILES

CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
InChi

InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19) 20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3
InChi Key

KQNZDYYTLMIZCT-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:4181
Gene

GBF1
Long gene name

golgi brefeldin A resistant guanine nucleotide exchange factor 1
Synonyms gene name
- golgi-specific brefeldin A resistance factor 1
Synonyms
- KIAA0248
- ARF1GEF
GenBank acession
- D87435
Locus

10q24.32
Discovery year

1999-01-14
Entrez gene record

8729
Pubmed identfication
- 9828135
Classification
- Sec7 family
VEGA ID

OTTHUMG00000018955

Identity

HGNC:15853
Gene

ARFGEF2
Long gene name

ADP ribosylation factor guanine nucleotide exchange factor 2
Synonyms gene name
- ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms
- BIG2
Synonyms name
- Brefeldin A-inhibited guanine nucleotide-exchange protein 2
GenBank acession
- AF084521
Locus

20q13.13
Discovery year

2001-06-21
Entrez gene record

10564
Pubmed identfication
- 10212200
RefSeq identity
- NM_006420
Classification
- ARFGEF family
- A-kinase anchoring proteins
- Armadillo like helical domain containing
VEGA ID

OTTHUMG00000032687