Anti-CD11c Antibody (ITGAX/1243)

• Catalog number
  A1474-100
• Price
  Please ask
• Size
  100 µg

• Antibody Target
  CD11c
• Target Alternative Name
  CD11 antigen-like family member C; Complement component 3 receptor 4 subunit; Integrin alpha-X; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); Leu M5 alpha subunit; Leukocyte adhesion glycoprotein p150 95 alpha chain; Myeloid membrane antigen alpha subunit; p150/95
• Antibody Type
  Monoclonal
• Clone
  ITGAX/1243
• Species Reactivities
  Human
• Immunogen Sequence
  Recombinant human ITGAX protein fragment (aa 637-827)
• Accession
  P20702
• Gene Id
  3687
• Appearance
  Colorless liquid
• Form
  Liquid
• Formulation
  In 10 mM PBS with 0.05% BSA & 0.05% azide
• Purification
  Protein A/G purification
• Application
  FC, IF, IHC
• Positive Control
  IHC: human Prostate Carcinoma, human Lung Carcinoma, human Follicular Lymphoma
• Application And Usages
  FC: 0.5-1 ug/1X106 cells, IF: 0.5-1 ug/ml, IHC: 1-2 ug/ml
• Description
  Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs). A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
• Storage Condition
  -20 °C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• Usage
  For Research Use Only! Not to be used in humans
• Handling
  The antibody solution should be gently mixed before use
• Western Blot Verified
  Not Verified
• Immunocytochemistry Verified
  Verified
• Immunofluorescence Verified
  Not Verified
• Immunoprecipitation Verified
  Not Verified
• FACS Verified
  Not Verified
• ELISA Verified
  Not Verified
• ChIP Verified
  Not Verified
• Dot Blot Verified
  Not Verified
• Flow Cytometry Verified
  Not Verified
• Data Sheet Link
• Additional description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD11c   ITGAX/1243  
• Gene symbol
  ITGAX
• Short name
  Anti-CD11c Antibody (ITGAX/1243)
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Isotype
  Mouse IgG2b, kappa
• Alternative name
  Antibody toCD11c (antibody to-) (integrin, alpha X (complement component 3 receptor 4 subunit)/1243)
• Alternative technique
  antibodies
• Alternative to gene target
  integrin, alpha X (complement component 3 receptor 4 subunit), CD11C and SLEB6, ITGAX and IDBG-28212 and ENSG00000140678 and 3687, metal ion binding, Cell surfaces, Itgax and IDBG-210550 and ENSMUSG00000030789 and 16411

Gene info

• Identity
  HGNC:6152
• Gene
  ITGAX
• Long gene name
  integrin subunit alpha X
• Synonyms gene
  • CD11C
• Synonyms gene name
  • integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
  • integrin, alpha X (complement component 3 receptor 4 subunit)
• Synonyms
  • CD11c
• Synonyms name
  • complement component 3 receptor 4 subunit
• GenBank acession
  • BC038237
• Locus
  16p11.2
• Discovery year
  1988-08-15
• Entrez gene record
  3687
• Pubmed identfication
  • 3284962
  • 2303426
• RefSeq identity
  • NM_000887
• Classification
  • Integrin alpha subunits
  • Complement system regulators and receptors
  • CD molecules
• VEGA ID
  OTTHUMG00000132465

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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