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Alternative_name
3Z)-N-(3-Chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl}methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
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Description
A specific, ATP-competitive small molecule inhibitor of the catalytic activity of Met. Displays selectivity for Met enzyme versus a panel of other tyrosine kinases with the following IC₅₀ values: Met = 0.02 μM, Flk = 1.3 μM, EGFR = >100 μM, PDGFßR = >20 μM, Tie2 = >100 μM, c-src = >10 μM, cdk2 = >10 μM, and FGFR-1 = 9.7 μM). Inhibition of the Met kinase activity by SU11274 leads to time- and dose-dependent reduced cell growth and induced G1 cell cycle arrest and apoptosis.
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CAS Number
658084-23-2
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₂₈H₃₀ClN₅O₄S
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Molecular Weight
568.09
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 10 mg/ml on warming)
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Handling
Protect from light
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Tag Line
A Met inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
36 months
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MDL Number
MFCD08276928
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PubChem CID
9549297
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SMILES
CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
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InChi
InChI=1S/C28H30ClN5O4S/c1-17-25(30-18(2)26(17)28(36)34-12-10-32(3)11-13- 34)16-23-22-15-21(8-9-24(22)31-27(23)35)39(37, 38)33(4)20-7-5-6-19(29)14-20/h5-9,14-16,30H,10-13H2,1-4H3,(H,31, 35)/b23-16-
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InChi Key
FPYJSJDOHRDAMT-KQWNVCNZSA-N
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MSDS Available
Yes
