TUG-891

Alternative_name

3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid, 4-[(4-Fluoro-4′-methyl[1,1′-biphenyl]-2-yl)methoxy]-benzenepropanoic acid
Description

TUG-891 is a potent GPR120 (free fatty acid receptor 4; FFAR4) agonist (pEC₅₀ values are 7.36 and 7.77 for human and mouse GPR120 respectively). Selective for GPR120 over free fatty acid receptors (pEC₅₀ = 4.19 for FFA1; displays no activity at FFA2 or FFA3).
CAS Number

1374516-07-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₃H₂₁FO₃
Molecular Weight

364.41
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~20 mg/ml)
Handling

Protect from air and light
Tag Line

A potent GPR120 (free fatty acid receptor 4; FFAR4) agonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

57522038
PubChem CID Link
SMILES

CC1=CC=C(C=C1)C2=C(C=C(C=C2)F)COC3=CC=C(C=C3)CCC(=O)O
InChi

InChI=1S/C23H21FO3/c1-16-2-7-18(8-3-16)22-12-9-20(24)14-19(22)15-27-21-10-4-17(5-11-21)6-13-23(25)26/h2-5,7-12,14H,6,13,15H2,1H3,(H,25,26)
InChi Key

LPGBXHWIQNZEJB-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

YES

Identity

HGNC:13825
Gene

ASPSCR1
Long gene name

ASPSCR1 tether for SLC2A4, UBX domain containing
Synonyms gene name
- alveolar soft part sarcoma chromosome region, candidate 1
- ASPSCR1, UBX domain containing tether for SLC2A4
Synonyms
- ASPS
- ASPL
- UBXD9
- UBXN9
- TUG
Synonyms name
- UBX domain protein 9
- Tether containing UBX domain for GLUT4
GenBank acession
- AF324219
Locus

17q25.3
Discovery year

2001-04-05
Entrez gene record

79058
Pubmed identfication
- 11244503
- 10506710
RefSeq identity
- NM_024083
Classification
- UBX domain containing
VEGA ID

OTTHUMG00000178438