UNC5D/UNC5H4 Antibody

• Catalog number
  bs-11494R
• Price
  Please ask
• Size
  0.1ml

• Long name
  UNC5D/UNC5H4 Primary Polyclonal Antibody
• Also known as
  UNC5D/UNC5H4 PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  UNC5D/UNC5H4
• Specificity
  This is a highly specific antibody against UNC5D/UNC5H4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Subcellular location
  Extracellular
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human UNC5H4
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Netrin receptor UNC5D; Netrin receptor Unc5h4; Protein unc 5 homolog D; Unc 5 homolog 4; Unc 5 homolog D C. elegans; Unc 5 homolog D; UNC 5D; Unc5h4; FLJ16019; KIAA1777.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  UNC5D/UNC5H4  
• Gene symbol
  UNC5D
• Short name
  Anti-UNC5D/UNC5H4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  UNC5D/UNC5H4 Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  unc-5 homolog D (C. elegans), UNC5D and IDBG-16693 and ENSG00000156687 and 137970, protein binding, Cell surfaces, Unc5d and IDBG-146351 and ENSMUSG00000063626 and 210801, UNC5D and IDBG-628993 and ENSBTAG00000010241 and 520004

Gene info

• Identity
  HGNC:18634
• Gene
  UNC5D
• Long gene name
  unc-5 netrin receptor D
• Synonyms gene name
  • unc-5 homolog D (C. elegans)
• Synonyms
  • KIAA1777
  • Unc5h4
• Synonyms name
  • Netrin receptor UNC5D
  • Protein unc-5 homolog 4
  • Protein unc-5 homolog D
• GenBank acession
  • AB055056
• Locus
  8p12
• Discovery year
  2002-05-13
• Entrez gene record
  137970
• Pubmed identfication
  • 18402767
• Classification
  • Ig-like cell adhesion molecule family
  • I-set domain containing
• VEGA ID
  OTTHUMG00000157145

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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