LDE-225
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Catalog number2892-5
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PricePlease ask
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Size5 mg
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Alternative_nameN-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide; Sonidegib; Erismodegib; NVP-LDE225
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DescriptionLDE225 is a potent and selective antagonist of Smoothened (Smo) with IC₅₀ values of 2.5 nM and 1.3 nM for human and mouse Hedgehog, respectively. LDE-225 induces dose-related inhibition of Hh and Smo-dependent tumour growth.
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CAS Number956697-53-3
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₂₆H₂₆F₃N₃O₃
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Molecular Weight485.5
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Cell Permeableyes
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Purity≥98% by HPLC
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SolubilitiesDMSO (~5 mg/ml)
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HandlingProtect from air and light
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Tag LineA potent and selective Smoothened (Smo) antagonist
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life36 months
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PubChem CID24775005
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SMILESCC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
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InChiInChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
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InChi KeyVZZJRYRQSPEMTK-CALCHBBNSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolEPM2A, EGR1
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Short nameLDE-225
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Alternative nameLDE-225
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Gene info
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Identity
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Gene
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Long gene nameEPM2A glucan phosphatase, laforin
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Synonyms gene name
- epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
- epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
- EPM2A, laforin glucan phosphatase
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-10-01
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Entrez gene record
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Pubmed identfication
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Classification
- Atypical dual specificity phosphatases
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameearly growth response 1
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1988-08-11
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Zinc fingers C2H2-type
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VEGA ID