anti- SMN antibody

• Catalog number
  FNab08031
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described.
• Immunogen
  survival of motor neuron 2, centromeric
• Synonyms
  C BCD541, Component of gems 1, FLJ76644, Gemin 1, SMN, SMN1, SMN1, SMN, SMN2, SMNC, SMNT, Survival motor neuron protein
• Calculated MW
  38 kDa
• Uniprot ID
  Q16637
• Specificity
  Human, Mouse
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Image1
  Immunohistochemical of paraffin-embedded human kidney using FNab08031(SMN2 antibody) at dilution of 1:100
• Image4
  K-562 cells were subjected to SDS PAGE followed by western blot with FNab08031(SMN2 antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  SMN  
• Gene symbol
  STMN1, SNRPN
• Short name
  anti- SMN antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- SMN (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6510
• Gene
  STMN1
• Long gene name
  stathmin 1
• Synonyms gene
  • LAP18
  • C1orf215
• Synonyms gene name
  • chromosome 1 open reading frame 215
  • stathmin 1/oncoprotein 18
• Synonyms
  • SMN
  • OP18
  • PR22
  • PP19
  • PP17
  • Lag
  • FLJ32206
• Synonyms name
  • oncoprotein 18
• GenBank acession
  • J04991
• Locus
  1p36.11
• Discovery year
  1990-12-17
• Entrez gene record
  3925
• Pubmed identfication
  • 2917975
• RefSeq identity
  • NM_005563
• Classification
  • Stathmins
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000007389

Gene info

• Identity
  HGNC:11164
• Gene
  SNRPN
• Long gene name
  small nuclear ribonucleoprotein polypeptide N
• Synonyms gene
  • PWCR
• Synonyms gene name
  • Prader-Willi syndrome chromosome region
• Synonyms
  • SMN
  • SM-D
  • HCERN3
  • SNRNP-N
  • SNURF-SNRPN
  • RT-LI
• Synonyms name
  • tissue-specific splicing protein
  • SM protein N
  • small nuclear ribonucleoprotein N
• GenBank acession
  • L80005
• Locus
  15q11.2
• Discovery year
  1992-08-24
• Entrez gene record
  6638
• Pubmed identfication
  • 1533223
• RefSeq identity
  • NM_003097
• Classification
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000129180

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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