NF-κB Inhibitor, SN50

• Catalog number
  2506-1000
• Price
  Please ask
• Size
  1 mg

• Alternative_name
  SN50; AAVALLPAVLLALLAPVQRKRQKLMP
• Description
  This peptide contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-κB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). SN50 inhibits translocation of the NF-κB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-κB nuclear translocation was 88% at 50 µg/ml (18 µM). In human monocytic THP-1 cells induced by LPS or TNFα there was 85% inhibition at 100 µg/ml.
• CAS Number
  213546-53-3
• Structure Available
  No
• Peptide sequence
  Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
• Salt Form
  TFA salt
• Molecular Formula
  C₁₂₉H₂₃₀N₃₆O₂₉S
• Molecular Weight
  2781.5
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  H₂O
• Handling
  Protect from air and moisture
• Tag Line
  A NF-κB Inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  24 months
• SMILES
  N/A
• InChi
  N/A
• InChi Key
  N/A
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  NF-κB   Inhibitor   SN50  
• Short name
  NF-κB Inhibitor, SN50
• Alternative name
  NF-κB suppressor, SN50

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