RAF265

• Catalog number
  2856-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-Methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridin-4-yl]oxy-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine; CHIR265
• Description
  RAF265 (CHIR-265) is a potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E (IC₅₀ of 3-60 nM); displays potent inhibition on VEGFR2 phosphorylation with EC₅₀ of 30 nM. RAF265 inhibits the growth of advanced human melanoma tumors.
• CAS Number
  927880-90-8
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₄H₁₆F₆N₆O
• Molecular Weight
  518.41
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>100 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and selective inhibitor of C-Raf/B-Raf/B-Raf V600E
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11656518
• PubChem CID Link
• SMILES
  CN1C2=C(C=C(C=C2)OC3=CC(=NC=C3)C4=NC=C(N4)C(F)(F)F)N=C1NC5=CC=C(C=C5)C(F)(F)F
• InChi
  InChI=1S/C24H16F6N6O/c1-36-19-7-6-15(10-17(19)34-22(36)33-14-4-2-13(3-5-14)23(25,26)27)37-16-8-9-31-18(11-16)21-32-12-20(35-21)24(28,29)30/h2-12H,1H3,(H,32,35)(H,33,34)
• InChi Key
  YABJJWZLRMPFSI-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RAF265  
• Short name
  RAF265
• Alternative name
  RAF265

Similar products