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Alternative_name
N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N'-hydroxyoctanediamide
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Description
Tubacin (Tubulin acetylation inducer) is a highly potent, selective, reversible, and cell-permeable inhibitor of histone deacetylase 6 (HDAC6, IC₅₀ = 4 nM). Displays 1000-fold more selectivity for HDAC6 over other HDACs. It inhibits α-tubulin deacetylation in mammalian cells. Unlike trichostatin A (TSA), which is a broad spectrum HDAC inhibitor, tubacin is specific for the tubulin deacetylase activity of HDAC6. Tubacin causes increased acetylation of α-tubulin, accumulation of polyubiquitinated proteins, and apoptosis. It does not affect global histone deacetylation, gene-expression profiling, or cell cycle progression mediated α-tubulin deacetylation in mammalian cells.
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CAS Number
537049-40-4
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₄₁H₄₃N₃O₇S
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Molecular Weight
721.86
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~ 10 mg/ml)
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Handling
Protect from light and mositure
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Tag Line
A potent HDAC6 inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
60 months
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PubChem CID
6675804
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SMILES
C1C(OC(OC1C2=CC=C(C=C2)CO)C3=CC=C(C=C3)NC(=O)CCCCCCC(=O)NO)CSC4=NC(=C (O4)C5=CC=CC=C5)C6=CC=CC=C6
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InChi
InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38 (30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33 (24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40, 45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
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InChi Key
BHUZLJOUHMBZQY-YXQOSMAKSA-N
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MSDS Available
Yes
