TC-E 5003

• Catalog number
  B1177-50
• Price
  Please ask
• Size
  50 mg

• Alternative_name
  N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide
• Description
  TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC₅₀ = 1.5 μM); displays no inhibitory activity against CARM1 and Set7/9 methyltransferases. Inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells.
• CAS Number
  17328-16-4
• Structure Available
  Yes
• Molecular Formula
  C₁₆H₁₄Cl₂N₂O₄S
• Molecular Weight
  401.26
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A selective protein arginine methyltransferase 1 (PRMT1) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00028183
• PubChem CID
  87052
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1NC(=O)CCl)S(=O)(=O)C2=CC=C(C=C2)NC(=O)CCl
• InChi
  InChI=1S/C16H14Cl2N2O4S/c17-9-15(21)19-11-1-5-13(6-2-11)25(23,24)14-7-3-12(4-8-14)20-16(22)10-18/h1-8H,9-10H2,(H,19,21)(H,20,22)
• InChi Key
  SHRCVZJKZJGIHQ-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  TC-E   5003  
• Gene symbol
  HLA-E, MT-TC, SMC2, SNAR-E, CD55, IPCEF1, SNRPE, KLRC3, TLE4
• Short name
  TC-E 5003
• Alternative name
  TC-E 5003

Gene info

• Identity
  HGNC:4962
• Gene
  HLA-E
• Long gene name
  major histocompatibility complex, class I, E
• GenBank acession
  • M20022
• Locus
  6p22.1
• Discovery year
  1988-05-11
• Entrez gene record
  3133
• Pubmed identfication
  • 3131426
• RefSeq identity
  • NM_005516
• Classification
  • C1-set domain containing
  • Histocompatibility complex
• VEGA ID
  OTTHUMG00000031155
• Locus Specific Databases
  • IMGT/HLA Database

Gene info

• Identity
  HGNC:7477
• Gene
  MT-TC
• Long gene name
  mitochondrially encoded tRNA-Cys (UGU/C)
• Synonyms gene
  • MTTC
• Synonyms gene name
  • tRNA cysteine
  • mitochondrially encoded tRNA cysteine
• Synonyms
  • trnC
• Locus
  mitochondria
• Discovery year
  1989-10-12
• Entrez gene record
  4511
• Pubmed identfication
  • 7219534
• Classification
  • Mitochondrially encoded transfer RNAs

Gene info

• Identity
  HGNC:14011
• Gene
  SMC2
• Long gene name
  structural maintenance of chromosomes 2
• Synonyms gene
  • SMC2L1
• Synonyms gene name
  • SMC2 (structural maintenance of chromosomes 2, yeast)-like 1
  • SMC2 structural maintenance of chromosomes 2-like 1 (yeast)
• Synonyms
  • hCAP-E
  • CAP-E
• GenBank acession
  • AF092563
• Locus
  9q31.1
• Discovery year
  2001-02-22
• Entrez gene record
  10592
• Pubmed identfication
  • 9789013
• Classification
  • Condensin I subunits
  • Condensin II subunits
  • Structural maintenance of chromosomes proteins
• VEGA ID
  OTTHUMG00000020401

Gene info

• Identity
  HGNC:34325
• Gene
  SNAR-E
• Long gene name
  small NF90 (ILF3) associated RNA E
• Synonyms gene name
  • small ILF3/NF90-associated RNA E
• GenBank acession
  • EU071072
• Locus
  19q13.32
• Discovery year
  2008-07-03
• Entrez gene record
  100170220
• Pubmed identfication
  • 17855395
• RefSeq identity
  • NR_024258
• Classification
  • Small NF90 (ILF3) associated RNAs

Gene info

• Identity
  HGNC:2665
• Gene
  CD55
• Long gene name
  CD55 molecule (Cromer blood group)
• Synonyms gene
  • DAF
• Synonyms gene name
  • decay accelerating factor for complement (CD55, Cromer blood group system)
  • CD55 molecule, decay accelerating factor for complement (Cromer blood group)
• Synonyms
  • CR
  • TC
  • CROM
• GenBank acession
  • BC001288
• Locus
  1q32.2
• Discovery year
  2001-06-22
• Entrez gene record
  1604
• RefSeq identity
  • NM_000574
• Classification
  • Blood group antigens
  • Complement system regulators and receptors
  • CD molecules
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000036255
• Locus Specific Databases
  • Blood Group Antigen Mutation Database
  • CD55base: Mutation registry for Decay-accelerating factor (CD55) deficiency (previously known as DAFbase)
  • LRG_127

Gene info

• Identity
  HGNC:21204
• Gene
  IPCEF1
• Long gene name
  interaction protein for cytohesin exchange factors 1
• Synonyms
  • PIP3-E
  • KIAA0403
• Synonyms name
  • phosphoinositide binding protein PIP3-E
• GenBank acession
  • AB007863
• Locus
  6q25.2
• Discovery year
  2009-02-27
• Entrez gene record
  26034
• Pubmed identfication
  • 11804589
  • 19756519
• RefSeq identity
  • NM_001130699
• Classification
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000015872

Gene info

• Identity
  HGNC:11161
• Gene
  SNRPE
• Long gene name
  small nuclear ribonucleoprotein polypeptide E
• Synonyms
  • Sm-E
• GenBank acession
  • M37716
• Locus
  1q32.1
• Discovery year
  1988-11-28
• Entrez gene record
  6635
• Pubmed identfication
  • 1835977
  • 2143747
• RefSeq identity
  • NM_003094
• Classification
  • Sm spliceosomal proteins
• VEGA ID
  OTTHUMG00000035985

Gene info

• Identity
  HGNC:6376
• Gene
  KLRC3
• Long gene name
  killer cell lectin like receptor C3
• Synonyms gene name
  • killer cell lectin-like receptor subfamily C, member 3
• Synonyms
  • NKG2-E
• GenBank acession
  • L14542
• Locus
  12p13.2
• Discovery year
  1998-01-16
• Entrez gene record
  3823
• Pubmed identfication
  • 9598306
• RefSeq identity
  • NM_002261
• Classification
  • C-type lectin domain containing
  • Killer cell lectin like receptors
• VEGA ID
  OTTHUMG00000167149

Gene info

• Identity
  HGNC:11840
• Gene
  TLE4
• Long gene name
  TLE family member 4, transcriptional corepressor
• Synonyms gene name
  • transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
  • transducin like enhancer of split 4
• Synonyms
  • E(spl)
  • ESG
  • GRG4
• GenBank acession
  • M99439
• Locus
  9q21.31
• Discovery year
  1993-12-20
• Entrez gene record
  7091
• Pubmed identfication
  • 8365415
• RefSeq identity
  • NM_001282748
• Classification
  • WD repeat domain containing
  • TLE family
  • Wnt enhanceosome complex
• VEGA ID
  OTTHUMG00000020072

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