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Alternative_name
1,5-Dideoxy-1,5-imino-D-galactitol, AT1001, 1-Deoxygalactostatin, 1-Deoxygalactonojirimycin, AT-1001, GR181413A
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Description
Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to α-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes.
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CAS Number
75172-81-5
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Salt Form
No
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Molecular Formula
C₆H₁₃NO₄ • HCl
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Molecular Weight
199.6
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Cell Permeable
True
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Purity
≥98%
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Solubilities
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Handling
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
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Tag Line
A competititve inhibitor of α-galactosidase
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Storage Condition
-20ºC
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Shipping Condition
Gel Pack
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Shelf Life
36 months
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MDL Number
MFCD00269962
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PubChem CID
11644097
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SMILES
C1C(C(C(C(N1)CO)O)O)O.Cl
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InChi
InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1
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InChi Key
ZJIHMALTJRDNQI-OLALXQGDSA-N
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MSDS Available
True
