MnTBAP Chloride

Alternative_name

Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Description

A cell-permeable superoxide dismutase (SOD) mimetic and potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Also inhibits neuronal apoptosis.
Structure Available

Yes
Salt Form

No
Molecular Formula

C₄₈H₂₈MnN₄O₈Cl
Molecular Weight

879.15
Cell Permeable

Yes
Purity

≥97% (MS)
Solubilities

Dissolve at 0.1 M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Handling

Protect from air and moisture
Tag Line

A SOD mimetic and peroxynitrite scavenger
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD06227760
PubChem CID

16760566
PubChem CID Link
SMILES

C1=CC(=CC=C1C2=C3C=CC(=C(C4=NC(=C(C5=CC=C([N-]5)C(=C6C=CC2=N6)C7=CC=C(C=C7)C(=O)O)C8=CC=C(C=C8)C(=O)O)C=C4)C9=CC=C(C=C9)C(=O)O)[N-]3)C(=O)O.[Cl-].[Mn+3]
InChi

InChI=1S/C48H30N4O8.ClH.Mn/c53-45(54)29-9-1-25(2-10-29)41-33-17-19-35(49-33)42(26-3-11-30(12-4-26)46(55)56)37-21-23-39(51-37)44(28-7-15-32(16-8-28)48(59)60)40-24-22-38(52-40)43(36-20-18-34(41)50-36)27-5-13-31(14-6-27)47(57)58;;/h1-24H,(H6,49,50,51,52,53,54,55,56,57,58,59,60);1H;/q;;+3/p-3
InChi Key

XHVDAQLNUQLQKW-UHFFFAOYSA-K
Data Sheet Link
MSDS Available

Yes