TRANCE/RANK L/TNFSF11

• Catalog number
  E21-R06
• Price
  Please ask
• Size
  10ug

• Shipping_Temperature
  Ambient
• Product_State
  Lyophilized
• Formulation_Description
  Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Storage
  Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
• Reconstitution
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Purity
  Greater than 95% as determined by reducing SDS-PAGE.
• Endotoxin
  Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
• Background
  Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
• Alternative Names
  Tumor necrosis factor ligand superfamily member 11;Tnfsf11;Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254
• Expression system
  E.coli

• Gene target
  TRANCE/RANK   L/TNFSF11  
• Gene symbol
  TNFSF11, TNFRSF11A, ANKFY1
• Short name
  TRANCE/RANK L/TNFSF11
• Species
  Mouse
• Alternative name
  TRANCE/RANK L/tumor necrosis factor (ligand) superfamily, member 11
• Alternative to gene target
  tumor necrosis factor (ligand) superfamily, member 11, CD254 and hRANKL2 and ODF and OPGL and OPTB2 and RANKL and sOdf and TRANCE, TNFSF11 and IDBG-28393 and ENSG00000120659 and 8600, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf11 and IDBG-182101 and ENSMUSG00000022015 and 21943, TNFSF11 and IDBG-628731 and ENSBTAG00000008924 and 513836

Gene info

• Identity
  HGNC:11926
• Gene
  TNFSF11
• Long gene name
  TNF superfamily member 11
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 11
• Synonyms
  • TRANCE
  • RANKL
  • OPGL
  • ODF
  • CD254
• GenBank acession
  • AF013171
• Locus
  13q14
• Discovery year
  1998-12-04
• Pubmed identfication
  • 9312132
  • 9367155
• Classification
  • Tumor necrosis factor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000016807

Gene info

• Identity
  HGNC:11908
• Gene
  TNFRSF11A
• Long gene name
  TNF receptor superfamily member 11a
• Synonyms gene
  • PDB2
  • LOH18CR1
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
  • Paget disease of bone 2
  • loss of heterozygosity, 18, chromosomal region 1
  • tumor necrosis factor receptor superfamily, member 11a, NFKB activator
• Synonyms
  • RANK
  • CD265
  • FEO
  • ODFR
  • TRANCE-R
• Synonyms name
  • osteoclast differentiation factor receptor
  • receptor activator of nuclear factor kappa B
  • familial expansile osteolysis
  • TRANCE receptor
• GenBank acession
  • AF018253
• Locus
  18q21.33
• Discovery year
  1998-12-04
• Entrez gene record
  8792
• Pubmed identfication
  • 9367155
  • 10615125
• Classification
  • CD molecules
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000132779
• Locus Specific Databases
  • LRG_194

Gene info

• Identity
  HGNC:20763
• Gene
  ANKFY1
• Long gene name
  ankyrin repeat and FYVE domain containing 1
• Synonyms
  • ANKHZN
  • KIAA1255
  • ZFYVE14
  • BTBD23
  • RANK-5
• Synonyms name
  • rabankyrin-5
• GenBank acession
  • AB033081
• Locus
  17p13.2
• Discovery year
  2003-04-29
• Entrez gene record
  51479
• Pubmed identfication
  • 10940552
  • 17273843
• RefSeq identity
  • NM_016376
• Classification
  • Zinc fingers FYVE-type
  • BTB domain containing
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000177727

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