TRANCE/RANK L/TNFSF11/CD254
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Catalog number
E21-K63
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Price
Please ask
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Size
10ug
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Shipping_Temperature
Ambient
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Product_State
Lyophilized
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Formulation_Description
Lyophilized from a 0.2 μm filtered solution of 20mM Tris,150mM NaCl,pH8.0.
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Storage
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Reconstitution
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
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Purity
Greater than 95% as determined by reducing SDS-PAGE.
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Endotoxin
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
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Background
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
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Alternative Names
CD254; ODF; OPGL; RANK L; TNFSF11; CD254; Osteoclast differentiation factor; Receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor ligand superfamily member 11
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Expression system
E.coli
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Gene target
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Gene symbol
TNFSF11, TNFRSF11A, ANKFY1
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Short name
TRANCE/RANK L/TNFSF11/CD254
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Species
Human
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Alternative name
TRANCE/RANK L/tumor necrosis factor (ligand) superfamily, member 11/CD254
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Alternative to gene target
tumor necrosis factor (ligand) superfamily, member 11, CD254 and hRANKL2 and ODF and OPGL and OPTB2 and RANKL and sOdf and TRANCE, TNFSF11 and IDBG-28393 and ENSG00000120659 and 8600, tumor necrosis factor receptor superfamily binding, Extracellular, Tnfsf11 and IDBG-182101 and ENSMUSG00000022015 and 21943, TNFSF11 and IDBG-628731 and ENSBTAG00000008924 and 513836
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Gene info
Gene info
Gene info
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