LY-341495

Alternative_name

2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid
Description

LY341495 is a potent, brain-permeable, and selective antagonist of the group II metabotropic glutamate receptors (mGluR), mGluR2 and mGluR3 (IC₅₀s = 21 and 14 nM, respectively, for human isoforms). It less effectively blocks mGluR8 and mGluR7 (IC₅₀s = 173 and 990 nM, respectively) and weakly antagonizes mGluR1, mGluR5, and mGluR4 (IC₅₀s = 6.8, 8.2, and 22 μM, respectively).
CAS Number

201943-63-7
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₀H₁₉NO₅
Molecular Weight

353.37
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (~ 3 mg/ml with slight warming)
Handling

Protect from air and light
Tag Line

A highly potent and selective group II metabotropic glutamate receptor antagonist
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
MDL Number

MFCD00949707
PubChem CID

9819927
PubChem CID Link
SMILES

C1C(C1C(CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O
InChi

InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
InChi Key

VLZBRVJVCCNPRJ-KPHUOKFYSA-N
Data Sheet Link
MSDS Available

Yes