Mouse anti TIAM

• Catalog number
  MUB1806S
• Price
  Please ask
• Size
  1 mL

• Category
  Primary Antibodies
• Long description
  Tiam1, also known as T-cell lymphoma invasion and metastasis-inducing protein 1, is a protein that in Humans is encoded by the TIAM1 gene. TIAM1 is tightly associate with BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one PDZ domain, two PH domains and one Ras-binding RBD domain. TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates Rac1, CDC42, and to a lesser extent RhoA. TIAM1 is found in virtually all tumor cell lines examined including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.
• Antibody come from
  F5S F6.2 is a Mouse monoclonal IgG2b antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with T-cell lymphoma invasion and metastasis-inducing protein 1 (Tiam1).
• Other description
  Each vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
• Clone
  F5S F6.2
• Antigen antibody binding interaction
  Mouse anti TIAM Antibody
• Antibody is raised in
  Mouse
• Antibody s reacts with
  Human
• Antibody s reacts with these species
  This antibody doesn't cross react with other species
• Antibody s specificity
  F5S F6.2 is a Mouse monoclonal directed anti the N-terminal region of Tiam1.
• Research interest
  Cancer,Immunology,Neurobiology
• Application
  Immunohistochemistry (frozen),Western blotting
• Antibody s suited for
  F5S F6.2 is useful for western blot and immunohistochemistry on frozen sections. Optimal antibody dilution should be determined by titration.
• Storage
  Store at 4°C, or in small aliquots at -20°C.
• Relevant references
  1. No references available
• Protein number
  see ncbi
• Warnings
  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
• Antibody s link
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Test
  Mouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
• Latin name
  Mus musculus

• Gene target
  TIAM  
• Gene symbol
  TIAM1, TIAM2
• Short name
  Mouse anti TIAM
• Technique
  Mouse, anti, antibody to, mouses
• Host
  mouse
• Isotype
  IgG2b
• Label
  unlabeled
• Species
  Mouse, Mouses
• Alternative name
  Mouse antibody to TIAM
• Alternative technique
  murine, antibodies

Gene info

• Identity
  HGNC:11805
• Gene
  TIAM1
• Long gene name
  TIAM Rac1 associated GEF 1
• Synonyms gene name
  • T-cell lymphoma invasion and metastasis 1
• Locus
  21q22.11
• Discovery year
  1994-04-22
• Entrez gene record
  7074
• Pubmed identfication
  • 8595894
  • 15340013
  • 19893486
• RefSeq identity
  • NM_003253
• Classification
  • Pleckstrin homology domain containing
  • PDZ domain containing
  • Dbl family Rho GEFs
• VEGA ID
  OTTHUMG00000084869

Gene info

• Identity
  HGNC:11806
• Gene
  TIAM2
• Long gene name
  TIAM Rac1 associated GEF 2
• Synonyms gene name
  • T-cell lymphoma invasion and metastasis 2
• Synonyms
  • STEF
• Synonyms name
  • Sif and Tiam1-like exchange factor
• Locus
  6q25.2-q25.3
• Discovery year
  1999-12-02
• Entrez gene record
  26230
• Pubmed identfication
  • 10512681
  • 19893486
• RefSeq identity
  • NM_012454
• Classification
  • PDZ domain containing
  • Dbl family Rho GEFs
  • Pleckstrin homology domain containing
• VEGA ID
  OTTHUMG00000015880

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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