OSI-027

• Catalog number
  2372-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; ASP4786
• Description
  OSI-027 is a potent mammalian target of rapamycin (mTOR) kinase inhibitor with potential antineoplastic activity. It binds to and inhibits both the raptor-mTOR (TOR complex 1 or TORC1) and the rictor-mTOR (TOR complex 2 or TORC2) complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation.
• CAS Number
  936890-98-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₁H₂₂N₆O₃
• Molecular Weight
  406.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~18 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A potent mTOR inhibitor
• Storage Condition
  -20 ̊C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD20275101
• PubChem CID
  44224160
• PubChem CID Link
• SMILES
  COC1=CC=CC2=CC(=C3C4=C(N=CNN4C(=N3)C5CCC(CC5)C(=O)O)N)N=C21
• InChi
  InChI=1S/C21H22N6O3/c1-30-15-4-2-3-13-9-14(25-16(13)15)17-18-19(22)23-10-24-27(18)20(26-17)11-5-7-12(8-6-11)21(28)29/h2-4,9-12H,5-8,22H2,1H3,(H,23,24)(H,28,29)/b17-14-
• InChi Key
  CDNMDRUIGNHEMR-VKAVYKQESA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  OSI-027  
• Short name
  OSI-027
• Alternative name
  OSI-027

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