PF-06840003

• Catalog number
  B2218-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  3‑(5-Fluoro‑1H‑indol-3-yl)pyrrolidine-2,5-dione; EOS 200271
• Description
  PF-06840003 is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC₅₀ = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC₅₀ = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC₅₀s = 1.7 and 4.7 µM, respectively).
• CAS Number
  198474-05-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₂H₉FN₂O₂
• Molecular Weight
  232.21
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  23063810
• PubChem CID Link
• SMILES
  C1C(C(=O)NC1=O)C2=CNC3=C2C=C(C=C3)F
• InChi
  InChI=1S/C12H9FN2O2/c13-6-1-2-10-7(3-6)9(5-14-10)8-4-11(16)15-12(8)17/h1-3,5,8,14H,4H2,(H,15,16,17)
• InChi Key
  MXKLDYKORJEOPR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PF-06840003  
• Short name
  PF-06840003
• Alternative name
  PF-06840003

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