AT-7519 hydrochloride

• Catalog number
  2816-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
• Description
  AT-7519 is a potent CDK inhibitor with potential antineoplastic activity. AT-7519 displays potent antiproliferative activity (40-940 nM) in a panel of human tumor cell lines, and the mechanism of action is shown to be consistent with the inhibition of CDK1 and CDK2 in solid tumor cell lines. AT-7519 causes cell cycle arrest followed by apoptosis in human tumor cells and inhibits tumor growth in human tumor xenograft models.
• CAS Number
  902135-91-5
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₆H₁₈Cl₃N₅O₂
• Molecular Weight
  418.71
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from light and moisture
• Tag Line
  A potent CDK inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  25033099
• PubChem CID Link
• SMILES
  C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl
• InChi
  InChI=1S/C16H17Cl2N5O2.ClH/c17-10-2-1-3-11(18)13(10)15(24)22-12-8-20-23-14(12)16(25)21-9-4-6-19-7-5-9;/h1-3,8-9,19H,4-7H2,(H,20,23)(H,21,25)(H,22,24);1H
• InChi Key
  PAOFPNGYBWGKCO-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  AT-7519   hydrochloride  
• Gene symbol
  NBN, GNPAT, SLC33A1
• Short name
  AT-7519 hydrochloride
• Alternative name
  AT-7519 hydrochloride

Gene info

• Identity
  HGNC:7652
• Gene
  NBN
• Long gene name
  nibrin
• Synonyms gene
  • NBS
  • NBS1
• Synonyms gene name
  • Nijmegen breakage syndrome 1 (nibrin)
• Synonyms
  • ATV
  • AT-V2
  • AT-V1
• GenBank acession
  • AF058696
• Locus
  8q21.3
• Discovery year
  1997-11-28
• Entrez gene record
  4683
• Pubmed identfication
  • 9590181
  • 9590180
• RefSeq identity
  • NM_001024688
• Classification
  • MRN complex
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000153546
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_158

Gene info

• Identity
  HGNC:4416
• Gene
  GNPAT
• Long gene name
  glyceronephosphate O-acyltransferase
• Synonyms
  • DHAPAT
  • DAPAT
  • DAP-AT
• Synonyms name
  • glycerone-phosphate O-acyltransferase
  • dihydroxyacetone phosphate acyltransferase
• GenBank acession
  • AF043937
• Locus
  1q42.2
• Discovery year
  1998-10-29
• Entrez gene record
  8443
• Pubmed identfication
  • 9459311
  • 9536089
• VEGA ID
  OTTHUMG00000038024

Gene info

• Identity
  HGNC:95
• Gene
  SLC33A1
• Long gene name
  solute carrier family 33 member 1
• Synonyms gene
  • ACATN
  • SPG42
• Synonyms gene name
  • acetyl-Coenzyme A transporter
  • spastic paraplegia 42 (autosomal dominant)
  • solute carrier family 33 (acetyl-CoA transporter), member 1
• Synonyms
  • AT-1
  • AT1
• GenBank acession
  • D88152
• Locus
  3q25.31
• Discovery year
  1999-02-12
• Entrez gene record
  9197
• Pubmed identfication
  • 9096318
  • 19061983
• RefSeq identity
  • NM_004733
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000158481

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