PicoProbe™ Fructose-1,6-Bisphosphatase Inhibitor Screening Kit (F)

• Catalog number
  K399-100
• Price
  Please ask
• Size
  100 assays

• Description
  Simple assay for high-throughput screening of FBP1 inhibitors/activators
• Summary
  • Detection method- Fluorescence (Ex/Em= 535/587 nm) • Application-Screening/characterizing/studying DHFR inhibitors/activators
• Detection Method
  (Ex/Em= 535/587 nm)
• Species Reactivity
  Human
• Applications
  Screening/characterizing/studying FBP1 inhibitors/activators
• Sample Type
  Not Applicable
• Features Benefits
  • Simple and reliable test to screen FBP1 inhibitors/activators • High-throughput compatible • Includes Inhibitor Control (AMP)
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Fructose-1,6-bispohphatase (FBP1) is responsible for the conversion of fructose-1,6-bisphosphate to fructose-6-phosphate in the rate determining step of gluconeogenesis. FBP1 is a tetramer that plays a role in regulating adiposity and appetite. FBP1 has emerged as an important therapeutic target to treat diabetes type 2 to regulate glucose levels during gluconeogenesis. In BioVision’s FBP1 Inhibitor Screening Kit, human FBP1 hydrolyzes fructose-1,6-bisphosphate to fructose-6-phosphate which oxidizes and reacts with a fluorogenic probe, that is detected at Ex/Em= 535/587 nm. The assay is fast, sensitive, high-throughput compatible and provides a quick and sensitive way for screening, studying and characterizing potential novel inhibitors of FBP1
• Data Sheet Link
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
• Conjugate
  Picoprobe low capacitance / high speed active probe arms and accessories. These probes arms have a FET amplifier either in or near the tip and are designed for measuring internal node voltages without capacitive loading the circuit

• Gene target
  Fructose-1   6-Bisphosphatase   Inhibitor   Screening   Kit  
• Short name
  ™ Fructose-1 6-Bisphosphatase Inhibitor Screening Kit (F)
• Alternative name
  PicoProbe™ Fructose-1,6-Bisphosphatase suppressor detection reagent (F)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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