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Alternative_name
(E)-N'-((4-oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
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Description
STAT5 Inhibitor suppresses STAT5 by targeting its SH2 domain (IC₅₀ = 47 µM against STAT5β SH2 domain EPO peptide binding activity). Comparatively, this compound displays reduced potency towards inhibiting the SH2 domain of STAT1, STAT3, or Lck (IC₅₀ > 500 µM). STAT5 Inhibitor has been shown to block STAT5/STAT5 DNA binding in K562 nuclear extracts. Cell-permeable.
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CAS Number
285986-31-4
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Structure Available
Yes
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Molecular Formula
C₁₆H₁₁N₃O₃
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Molecular Weight
293.3
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (10 mg/ml)
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Handling
Protect from air and light
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Tag Line
A Stat5 inhibitor
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Storage Condition
-20°C
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Shipping Condition
Gel pack
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Shelf Life
36 months
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MDL Number
MFCD00124694
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PubChem CID
2726045
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SMILES
C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=O)C3=CN=CC=C3
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InChi
InChI=1S/C16H11N3O3/c20-15-12(10-22-14-6-2-1-5-13(14)15)9-18-19-16(21)11-4-3-7-17-8-11/h1-10H,(H,19,21)
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InChi Key
DAVIKTBRCQWOGT-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
