anti-BDNF Antibody

• Catalog number
  XP-5108Bt
• Price
  Please ask
• Size
  0.05 mg

• Gene info
  Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes NGF, NT3, and NT4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF is a potent neurotrophic factor that supports the growth and survivability of nerve and/or glial cells. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells. BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non neuronal cells. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients. In addition, functional studies showed that age-associated changes in BDNF-mediated pathways can enhance inflammation and increase myocardial injury after myocardial infarction in the aging heart.
• Gene names
  ANON2, BULN2Brain-derived neurotrophic factor, Abrineurin, BDNF
• Antibodie s label
  Biotin
• Purity
  Anti-hBDNF specific antibody was purified by affinity chromatography and then biotinylated.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Antigen
  Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBDNF (human BDNF).
• Immuno application
  ELISA, Western Blot
• Antibody advice
  ELISA:To detect hBDNF by direct ELISA (using 100 μL/well antibody solution) this antibody can be used at a concentration of 0.15 - 0.30 ug/mL. Used in conjunction with compatible secondary reagents, allows the detection of at least 0.2 ng/well of recombinant hBDNF. Western Blot:To detect hBDNF by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBDNF is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
• Keep at
  BDNF antibody is stable for at least 2 years from date of receipt at -20 grades C. The reconstituted antibody is stable for at least two weeks at 2-8 grades C. Frozen aliquots are stable for at least 6 months when stored at -20 grades C. Avoid repeated freeze-thaw cycles.
• Works with
  Human
• Omim nr
  114900
• Ncbi nr
  P23560
• Vial with antibody
  Lyophilized
• NCBI GENE nr
  627
• GENE symbol
  BDNF
• Antigene name
  brain-derived neurotrophic factor
• Source
  Homo sapiens
• Protein nr
  P23560
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  BDNF  
• Gene symbol
  BDNF, BDNF-AS
• Short name
  anti-BDNF Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toBDNF (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  brain-derived neurotrophic factor, ANON2 and BULN2, BDNF and IDBG-36817 and ENSG00000176697 and 627, growth factor activity, Extracellular, Bdnf and IDBG-195506 and ENSMUSG00000048482 and 12064, BDNF and IDBG-636102 and ENSBTAG00000008134 and 617701

Gene info

• Identity
  HGNC:1033
• Gene
  BDNF
• Long gene name
  brain derived neurotrophic factor
• Synonyms name
  • neurotrophin
• GenBank acession
  • AB038670
• Locus
  11p14.1
• Discovery year
  1991-01-15
• Entrez gene record
  627
• Pubmed identfication
  • 2236018
  • 1889806
  • 17942328
  • 17493809
• RefSeq identity
  • NM_170735
• Classification
  • Neurotrophins
• VEGA ID
  OTTHUMG00000178797

Gene info

• Identity
  HGNC:20608
• Gene
  BDNF-AS
• Long gene name
  BDNF antisense RNA
• Synonyms gene
  • BDNFOS
• Synonyms gene name
  • BDNF opposite strand (non-protein coding)
  • BDNF antisense RNA (non-protein coding)
• Synonyms
  • BT2A
  • BT2B
  • BT2C
  • BT2D
  • NCRNA00049
  • BDNF-AS1
  • BDNFAS
• Synonyms name
  • non-protein coding RNA 49
  • BDNF antisense RNA 1 (non-protein coding)
• GenBank acession
  • AY054391
• Locus
  11p14.1
• Discovery year
  2005-02-01
• Entrez gene record
  497258
• Pubmed identfication
  • 15666411
  • 22446693
  • 28777258
• RefSeq identity
  • NR_002832
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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