MCC950 sodium

• Catalog number
  9686-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CP-456,773; CRID3
• Description
  MCC950 sodium is a potent and selective NLRP3 inflammasome inhibitor. It blocks the release of IL-1β in macrophages primed with LPS and activated with ATP or nigericin, but it does not inhibit NLRP1, NLRC4, AIM2, TLR2 signaling or priming of NLRP3. Also glutathione S-transferase omega 1 inhibitor. Potential therapeutic agent for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases.
• CAS Number
  256373-96-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₂₃N₂NaO₅S
• Molecular Weight
  426.46
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>35 mg/ml) or H2O (>30 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent and selective NLRP3 inflammasome inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  91826093
• PubChem CID Link
• SMILES
  CC(C)(C1=COC(=C1)S(=O)(=O)[N-]C(=O)NC2=C3CCCC3=CC4=C2CCC4)O.[Na+]
• InChi
  InChI=1S/C20H24N2O5S.Na/c1-20(2,24)14-10-17(27-11-14)28(25,26)22-19(23)21-18-15-7-3-5-12(15)9-13-6-4-8-16(13)18;/h9-11,24H,3-8H2,1-2H3,(H2,21,22,23);/q;+1/p-1
• InChi Key
  LFQQNXFKPNZRFT-UHFFFAOYSA-M
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  MCC950   sodium  
• Short name
  MCC950 sodium
• Alternative name
  MCC950 sodium

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