PRL-3 Inhibitor

• Catalog number
  B1825-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-[[5-Bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone; P0108; BR-1; PTP4A3 Inhibitor
• Description
  P0108 is a potent inhibitor of phosphatase of regenerating liver-3 (PRL-3) (IC₅₀ = 0.9 μM). It reduces the invasive properties of mouse melanoma B16F10 cells in a cellular model. Sensitizes PRL-3-expressing cancer cells to chemotherapeutics. Inhibits dephosphorylation of tyrosine-783 of integrin β1 in BGC823 and SW480 cells.
• CAS Number
  893449-38-2
• Structure Available
  Yes
• Molecular Formula
  C₁₇H₁₁Br₂NO₂S₂
• Molecular Weight
  485.2
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (~ 25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent phosphatase of regenerating liver-3 (PRL-3) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• MDL Number
  MFCD11045303
• PubChem CID
  73707371
• PubChem CID Link
• SMILES
  C1=CC=C(C(=C1)COC2=C(C=C(C=C2)Br)C=C3C(=O)NC(=S)S3)Br
• InChi
  InChI=1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
• InChi Key
  HXNBAOLVPAWYLT-OVCLIPMQSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PRL-3   Inhibitor  
• Gene symbol
  PTP4A3, PRL, SMR3B, PTP4A2P1, PTP4A1, MIR1302-3, MIR509-3, MIR7-3
• Short name
  PRL-3 Inhibitor
• Alternative name
  PRL-3 suppressor

Gene info

• Identity
  HGNC:9636
• Gene
  PTP4A3
• Long gene name
  protein tyrosine phosphatase 4A3
• Synonyms gene name
  • protein tyrosine phosphatase type IVA, member 3
• Synonyms
  • PRL-3
  • PRL-R
  • PRL3
• Synonyms name
  • phosphatase of regenerating liver 3
• GenBank acession
  • AF041434
• Locus
  8q24.3
• Discovery year
  1999-09-09
• Entrez gene record
  11156
• RefSeq identity
  • NM_032611
• Classification
  • Protein tyrosine phosphatase 4A family
• VEGA ID
  OTTHUMG00000164490

Gene info

• Identity
  HGNC:9445
• Gene
  PRL
• Long gene name
  prolactin
• GenBank acession
  • D00411
• Locus
  6p22.3
• Discovery year
  1986-01-01
• Entrez gene record
  5617
• RefSeq identity
  • NM_000948
• Classification
  • Growth hormone family
  • Neuropeptides
• VEGA ID
  OTTHUMG00000016111

Gene info

• Identity
  HGNC:17326
• Gene
  SMR3B
• Long gene name
  submaxillary gland androgen regulated protein 3B
• Synonyms gene
  • PROL3
• Synonyms gene name
  • proline rich 3
  • submaxillary gland androgen regulated protein 3 homolog B (mouse)
• Synonyms
  • P-B
  • PRL3
• GenBank acession
  • D29833
• Locus
  4q13.3
• Discovery year
  2002-01-03
• Entrez gene record
  10879
• Pubmed identfication
  • 7982889
  • 479131
• RefSeq identity
  • NM_006685
• VEGA ID
  OTTHUMG00000129396

Gene info

• Identity
  HGNC:9637
• Gene
  PTP4A2P1
• Long gene name
  PTP4A2 pseudogene 1
• Synonyms gene
  • PTP4AP1
• Synonyms gene name
  • protein tyrosine phosphatase type IVA pseudogene 1
  • protein tyrosine phosphatase type IVA, member 2 pseudogene 1
• Synonyms
  • h-PRL-1
• Locus
  17q21.2
• Discovery year
  1996-03-14
• Entrez gene record
  5767
• Pubmed identfication
  • 8661118
  • 8931711
• RefSeq identity
  • NG_004085
• VEGA ID
  OTTHUMG00000180239

Gene info

• Identity
  HGNC:9634
• Gene
  PTP4A1
• Long gene name
  protein tyrosine phosphatase 4A1
• Synonyms gene name
  • protein tyrosine phosphatase type IVA, member 1
• Synonyms
  • PTPCAAX1
  • PRL-1
  • PRL1
• Synonyms name
  • phosphatase of regenerating liver 1
• GenBank acession
  • U48296
• Locus
  6q12
• Discovery year
  1998-09-02
• Entrez gene record
  7803
• Pubmed identfication
  • 9642300
• Classification
  • Protein tyrosine phosphatase 4A family
• VEGA ID
  OTTHUMG00000014949

Gene info

• Identity
  HGNC:35295
• Gene
  MIR1302-3
• Long gene name
  microRNA 1302-3
• Synonyms gene
  • MIRN1302-3
• Synonyms
  • hsa-mir-1302-3
• Locus
  2q14.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302128
• RefSeq identity
  • NR_031632
• Classification
  • MicroRNA MIR1302 family

Gene info

• Identity
  HGNC:33675
• Gene
  MIR509-3
• Long gene name
  microRNA 509-3
• Synonyms gene
  • MIRN509-3
• Synonyms
  • hsa-mir-509-3
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126337
• RefSeq identity
  • NR_030629
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:31640
• Gene
  MIR7-3
• Long gene name
  microRNA 7-3
• Synonyms gene
  • MIRN7-3
• Synonyms
  • hsa-mir-7-3
• Locus
  19p13.3
• Discovery year
  2004-04-23
• Entrez gene record
  407045
• RefSeq identity
  • NR_029607
• Classification
  • MicroRNA MIR7 family

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