ASP-3026

• Catalog number
  B1296-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
• Description
  ASP-3026 is a potent, and ATP-competitive inhibitor of ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase) with IC₅₀ value of 3.5 nM. It also inhibits ROS (IC₅₀ = 8.9 nM) and ACK (IC₅₀ = 5.8 nM). ASP3026 has been shown to overcome Crizotinib (Cat. No. 1934) resistance in non-small cell lung cancer.
• CAS Number
  1097917-15-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₉H₄₀N₈O₃S
• Molecular Weight
  580.74
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent, and ATP-competitive inhibitor of ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase)
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  25134326
• PubChem CID Link
• SMILES
  CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC=NC(=N2)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
• InChi
  InChI=1S/C29H40N8O3S/c1-21(2)41(38,39)27-8-6-5-7-25(27)33-29-31-20-30-28(34-29)32-24-10-9-23(19-26(24)40-4)36-13-11-22(12-14-36)37-17-15-35(3)16-18-37/h5-10,19-22H,11-18H2,1-4H3,(H2,30,31,32,33,34)
• InChi Key
  MGGBYMDAPCCKCT-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  ASP-3026  
• Gene symbol
  TMPRSS11D, ASIP, ASPA, ROPN1L, ATG5, ASPM, A1CF, TRD-GTC4-1, TRD-GTC5-1, TRD-GTC6-1
• Short name
  ASP-3026
• Alternative name
  L-aspartic acid-3026

Gene info

• Identity
  HGNC:24059
• Gene
  TMPRSS11D
• Long gene name
  transmembrane serine protease 11D
• Synonyms gene name
  • transmembrane protease, serine 11D
• Synonyms
  • HAT
  • ASP
• Synonyms name
  • airway trypsin like protease
  • adrenal secretory serine protease
• GenBank acession
  • AB002134
• Locus
  4q13.2
• Discovery year
  2005-03-11
• Entrez gene record
  9407
• Pubmed identfication
  • 9565616
  • 9070615
• RefSeq identity
  • NM_004262
• Classification
  • Type II transmembrane serine proteases
• VEGA ID
  OTTHUMG00000129300

Gene info

• Identity
  HGNC:745
• Gene
  ASIP
• Long gene name
  agouti signaling protein
• Synonyms gene
  • AGTIL
• Synonyms gene name
  • agouti (mouse)-signaling protein
  • agouti signaling protein, nonagouti homolog (mouse)
• Synonyms
  • ASP
• Synonyms name
  • nonagouti homolog (mouse)
• Locus
  20q11.22
• Discovery year
  1995-01-03
• Entrez gene record
  434
• Pubmed identfication
  • 7937887
  • 7757071
• VEGA ID
  OTTHUMG00000032289

Gene info

• Identity
  HGNC:756
• Gene
  ASPA
• Long gene name
  aspartoacylase
• Synonyms gene name
  • aspartoacylase (aminoacylase 2, Canavan disease)
• Synonyms
  • ASP
  • ACY2
• Synonyms name
  • aminoacylase 2
  • Canavan disease
• GenBank acession
  • S67156
• Locus
  17p13.2
• Discovery year
  1993-12-09
• Entrez gene record
  443
• Pubmed identfication
  • 8252036
• RefSeq identity
  • NM_000049
• VEGA ID
  OTTHUMG00000090655
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:24060
• Gene
  ROPN1L
• Long gene name
  rhophilin associated tail protein 1 like
• Synonyms gene name
  • ropporin 1-like
  • rhophilin associated tail protein 1-like
• Synonyms
  • ASP
  • FLJ25776
  • RSPH11
• Synonyms name
  • radial spoke head 11 homolog (Chlamydomonas)
• GenBank acession
  • AF239723
• Locus
  5p15.2
• Discovery year
  2004-07-05
• Entrez gene record
  83853
• Pubmed identfication
  • 11278869
• RefSeq identity
  • NM_031916
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000090507

Gene info

• Identity
  HGNC:589
• Gene
  ATG5
• Long gene name
  autophagy related 5
• Synonyms gene
  • APG5L
• Synonyms gene name
  • APG5 (autophagy 5, S. cerevisiae)-like
  • APG5 autophagy 5-like (S. cerevisiae)
  • ATG5 autophagy related 5 homolog (S. cerevisiae)
• Synonyms
  • ASP
  • APG5
  • hAPG5
• GenBank acession
  • Y11588
• Locus
  6q21
• Discovery year
  1999-09-16
• Entrez gene record
  9474
• Pubmed identfication
  • 9563500
  • 11349150
  • 15778222
• RefSeq identity
  • NM_004849
• Classification
  • Autophagy related
• VEGA ID
  OTTHUMG00000016193

Gene info

• Identity
  HGNC:19048
• Gene
  ASPM
• Long gene name
  assembly factor for spindle microtubules
• Synonyms gene
  • MCPH5
• Synonyms gene name
  • microcephaly, primary autosomal recessive 5
  • asp (abnormal spindle)-like, microcephaly associated (Drosophila)
  • asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
  • abnormal spindle microtubule assembly
• Synonyms
  • Calmbp1
  • ASP
  • FLJ10517
  • FLJ10549
• GenBank acession
  • AY367065
• Locus
  1q31.3
• Discovery year
  2002-08-13
• Entrez gene record
  259266
• Pubmed identfication
  • 11078481
• RefSeq identity
  • NM_018136
• VEGA ID
  OTTHUMG00000036277

Gene info

• Identity
  HGNC:24086
• Gene
  A1CF
• Long gene name
  APOBEC1 complementation factor
• Synonyms
  • ACF
  • ASP
  • ACF64
  • ACF65
  • APOBEC1CF
• GenBank acession
  • AF271790
• Locus
  10q11.23
• Discovery year
  2007-11-23
• Entrez gene record
  29974
• Pubmed identfication
  • 11815617
  • 11072063
• RefSeq identity
  • NM_014576
• Classification
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000018240

Gene info

• Identity
  HGNC:34551
• Gene
  TRD-GTC4-1
• Long gene name
  tRNA-Asp (GTC) 4-1
• Synonyms gene
  • TRNAD2
• Synonyms gene name
  • transfer RNA aspartic acid 2 (anticodon GUC)
  • transfer RNA-Asp (GTC) 4-1
• Synonyms
  • tRNA-Asp-GTC-4-1
• GenBank acession
  • HG983677
• Locus
  9q21.13
• Discovery year
  2008-08-29
• Entrez gene record
  100188994
• Classification
  • Low confidence cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34620
• Gene
  TRD-GTC5-1
• Long gene name
  tRNA-Asp (GTC) 5-1
• Synonyms gene
  • TRNAD3
• Synonyms gene name
  • transfer RNA aspartic acid 3 (anticodon GUC)
  • transfer RNA-Asp (GTC) 5-1
• Synonyms
  • tRNA-Asp-GTC-5-1
• GenBank acession
  • HG983678
• Locus
  5q31.3
• Discovery year
  2008-08-29
• Entrez gene record
  100189061
• Classification
  • Low confidence cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34712
• Gene
  TRD-GTC6-1
• Long gene name
  tRNA-Asp (GTC) 6-1
• Synonyms gene
  • TRNAD7
• Synonyms gene name
  • transfer RNA aspartic acid 7 (anticodon GUC)
  • transfer RNA-Asp (GTC) 6-1
• Synonyms
  • tRNA-Asp-GTC-6-1
• GenBank acession
  • HG983679
• Locus
  3q27.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189150
• Classification
  • Low confidence cytoplasmic transfer RNAs

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