CP-640186

Alternative_name

[(3R)-1'-(9-anthracenylcarbonyl)[1,4'-bipiperidin]-3-yl]-4-morpholinyl-methanone
Description

CP-640186 is a mixed ACC (Acetyl-CoA carboxylase) inhibitor (ACC-1 IC₅₀ = 53 nM; ACC-2 IC₅₀ = 61 nM) that lowers malonyl-CoA levels and inhibits hepatic fatty acid and triglyceride synthesis in vitro and in vivo, as well as stimulates muscle fatty acid oxidation and lowers whole body RQ in rats.
CAS Number

591778-68-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₃₀H₃₅N₃O₃
Molecular Weight

485.62
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A mixed ACC (Acetyl-CoA carboxylase) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

449097
PubChem CID Link
SMILES

C1CC(CN(C1)C2CCN(CC2)C(=O)C3=C4C=CC=CC4=CC5=CC=CC=C53)C(=O)N6CCOCC6
InChi

InChI=1S/C30H35N3O3/c34-29(32-16-18-36-19-17-32)24-8-5-13-33(21-24)25-11-14-31(15-12-25)30(35)28-26-9-3-1-6-22(26)20-23-7-2-4-10-27(23)28/h1-4,6-7,9-10,20,24-25H,5,8,11-19,21H2/t24-/m1/s1
InChi Key

LDQKDRLEMKIYMC-XMMPIXPASA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:1366
Gene

ADAMTS13
Long gene name

ADAM metallopeptidase with thrombospondin type 1 motif 13
Synonyms gene
- C9orf8
Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13
Synonyms
- VWFCP
- TTP
- vWF-CP
- FLJ42993
- MGC118899
- MGC118900
- DKFZp434C2322
GenBank acession
- AJ011374
Locus

9q34.2
Discovery year

1999-08-23
Entrez gene record

11093
Pubmed identfication
- 11557746
- 11535495
RefSeq identity
- NM_139025
Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
VEGA ID

OTTHUMG00000020876
Locus Specific Databases
- LRG_544