RSK3, Active

Synonyms

RSK, ribosomal protein S6 kinase, 90kDa, polypeptide 2
Alternative_names

RSK, ribosomal protein S6 kinase, 90kDa, polypeptide 2
Description

Involved in signal transduction
Recombinant

Yes
Source

Baculovirus (Sf9 insect cells)
Purity by SDS PAGE

≥90%
Assay

SDS-PAGE
Activity Specifications test method

The specific activity of RSK3 was determined to be 131 nmol /min/mg as per activity assay protocol.
Molecular Weight

112.0 kDa
Storage Temp

-80°C
Shipping

dry ice
Shelf Life

12 months
Concentration

0.1mg/ml
Appearance

Liquid
Physical form description

Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Background Information

RSK3 is a member of the RSK (ribosomal S6 kinase) family that encodes a 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal (1). RSK3 mRNA is widely expressed and is activated by growth factors, serum and phorbol ester. Upon stimulation, RSK3 translocates to the cell nucleus and phosphorylates nuclear proteins. RSK3 can bind to ERK1/2 and this association increases the duration of RSK3 activation (2).
Handling

Centrifuge the vial prior to opening.
Usage

For Research Use Only! Not to be used in humans
Datasheet

Identity

HGNC:10431
Gene

RPS6KA2
Long gene name

ribosomal protein S6 kinase A2
Synonyms gene name
- ribosomal protein S6 kinase, 90kD, polypeptide 2
Synonyms
- RSK3
- HU-2
GenBank acession
- L07598
Locus

6q27
Discovery year

1994-07-11
Entrez gene record

6196
Pubmed identfication
- 8141249
RefSeq identity
- NM_021135
Classification
- MicroRNA protein coding host genes
- AGC family kinases
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000016007