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Stock availabilitIn Stock
In Stock
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CAS number
347174-05-4
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Description
Ferroptosis Inhibitor
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Molecular weight
262,4 g/mol
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Primary research fields
Cancer, Apoptosis, Cell Signaling, Neuroscience
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Other name
Ethyl 3-amino-4-(cyclohexylamino)benzoate
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C15H22N2O2
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Origin
Synthetic
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Purity pourcentage
>98% (TLC); NMR (Conforms)
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Soluble in
Soluble in DMSO (100 mg/ml) or ethanol (100 mg/ml)
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Physical appearance
Tan powder
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Skin irritation (Category 2), H315 Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Hazard statements: H315 Causes skin irritation. H319 Causes serious eye irritation. Precautionary statements: P260 Do not breathe dust/fume/gas/mist/vapours/spray P264 Wash skin thoroughly after handling. P280 Wear protective gloves. P302 + P352 IF ON SKIN: Wash with plenty of soap and water. P304 + 340 If INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing P305 + 351+ + 338 IF IN EYES: Rinse continuously with water for several minutes. Remove contact lenses if present and easy to do so- continue rinsing. P333 + 313 If skin irritation or a rash occurs: Get medical advice/attention
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PubChem number
Refer to PubChem
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Scientific context
Ferrostatin-1 inhibits ferroptosis (EC50=60 nM), an iron-dependent form of nonapoptotic cell death. It is especially potent of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices (1). It also blocks the cytotoxic effects of sorafenib in hepatocellular carcinoma cells (2), and inhibits oxidative lipid damage and cell death in diverse disease models (3).
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Bibliography
1. Dixon S.J., et al. (2012) Cell. 149: 1060. 2. Louandre C., et al. (2013) Int. J. Cancer. 133: 1732. 3. Skouta R., et al. (2014) J. Am. Chem. Soc. 136: 4551.
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Release date
12-Feb-2015
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Ferrostatin-1 (SIH-525), a Ferroptosis Inhibitor. CAS #: 347174-05-4. Molecular Formula: C15H22N2O2. Molecular Weight: 262.4 g/mol. Chemical structure of Ferrostatin-1, a Ferroptosis Inhibitor (SIH-525). CAS # 347174-05-4. Molecular Formula: C15H22N2O2.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
