RGB-286638,  free base

• Catalog number
  2886-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-[3-[4-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]phenyl]-4-oxo-1H-indeno[1,2-c]pyrazol-5-yl]-3-morpholin-4-ylurea
• Description
  RGB-286638 is a potent and selective cyclin-dependent kinase (CDK) inhibitor with IC₅₀ values of 1, 2, 3 and 44 nM for CDK9, CDK1, CDK2, and CDK4, respectively.  Less potent against cyclin H-CDK7 and cyclin D3-CDK6. It inhibits cell cycle progression in cancer cells by targeting CDKs, and is also found to induce apoptosis. In a range of pre-clinical models of solid and hematological tumors, RGB-286638 treatment results in tumor regression and increased survival.
• CAS Number
  784210-88-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₉H₃₅N₇O₄
• Molecular Weight
  545.63
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent and selective cyclin-dependent kinase (CDK) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  11285002
• PubChem CID Link
• SMILES
  COCCN1CCN(CC1)CC2=CC=C(C=C2)C3=NNC4=C3C(=O)C5=C4C=CC=C5NC(=O)NN6CCOCC6
• InChi
  InChI=1S/C29H35N7O4/c1-39-16-13-34-9-11-35(12-10-34)19-20-5-7-21(8-6-20)26-25-27(32-31-26)22-3-2-4-23(24(22)28(25)37)30-29(38)33-36-14-17-40-18-15-36/h2-8H,9-19H2,1H3,(H,31,32)(H2,30,33,38)
• InChi Key
  XLSYZSRXVVCHLS-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  RGB-286638    free base  
• Short name
  RGB-286638,  free base
• Alternative name
  RGB-286638,  free base

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