AMG-925

Alternative_name

2-hydroxy-1-[2-[[9-(4-methylcyclohexyl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-yl]amino]-7,8-dihydro-5H-1,6-naphthyridin-6-yl]ethenone
Description

AMG-925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC₅₀ of 1 nM and 3 nM, respectively. It inhibits the proliferation of a panel of human tumor cell lines including Colo205 (Rb(+)) and U937 (FLT3(WT)) and induces cell death in MOLM13 (FLT3(ITD)).
CAS Number

1401033-86-0
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₆H₂₉N₇O₂
Molecular Weight

471.55
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO
Handling

Protect from air and light
Tag Line

A potent and orally bioavailable dual FLT3/CDK4 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

60202647
PubChem CID Link
SMILES

CC1CCC(CC1)N2C3=C(C=CN=C3)C4=CN=C(N=C42)NC5=NC6=C(CN(CC6)C(=O)CO)C=C5
InChi

InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)
InChi Key

BBUVDDPUURMFOX-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes