IDE-1

Alternative_name

1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
Description

Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC₅₀ = 125 nM). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling pathway.
CAS Number

1160927-48-9
Structure Available

Yes
Salt Form

No
Molecular Formula

C₁₅H₁₈N₂O₅
Molecular Weight

306.31
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (25 mg/ml) or EtOH (12 mg/ml with warming)
Handling

Protect from air and light
Tag Line

A stem cell differentiating agent
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24months
MDL Number

MFCD17480459
PubChem CID

23749403
PubChem CID Link
SMILES

C1=CC=C(C(=C1)C=NNC(=O)CCCCCC(=O)O)C(=O)O
InChi

InChI=1S/C15H18N2O5/c18-13(8-2-1-3-9-14(19)20)17-16-10-11-6-4-5-7-12(11)15(21)22/h4-7,10H,1-3,8-9H2,(H,17,18)(H,19,20)(H,21,22)/b16-10+
InChi Key

ABKJCDILEUEJSH-MHWRWJLKSA-N
Data Sheet Link
MSDS Available

Yes

Gene target

IDE-1
Gene symbol

IDE, IGHVII-1-1, MIR1-1, TRUND-NNN8-1, TRUND-NNN7-1, IGKV1OR2-1, MIR101-1, MIR1289-1, MIR16-1
Short name

IDE-1
Alternative name

insulin-degrading enzyme-1
Alternative to gene target

insulin-degrading enzyme, INSULYSIN, IDE and IDBG-82456 and ENSG00000119912 and 3416, metal ion binding, nuclei, Ide and IDBG-161417 and ENSMUSG00000056999 and 15925, IDE and IDBG-637578 and ENSBTAG00000019759 and 523752

Identity

HGNC:5670
Gene

IGHVII-1-1
Long gene name

immunoglobulin heavy variable (II)-1-1 (pseudogene)
Synonyms gene name
- immunoglobulin heavy variable (II)-1-1
- immunoglobulin heavy variable (II)-1-1 pseudogene
Synonyms
- IGHV(II)-1-1
GenBank acession
- AB019441
Locus

14q32.33
Discovery year

2000-04-17
Entrez gene record

28377
RefSeq identity
- NG_001019
Classification
- Immunoglobulin heavy locus at 14q32.33
VEGA ID

OTTHUMG00000152325

Identity

HGNC:5760
Gene

IGKV1OR2-1
Long gene name

immunoglobulin kappa variable 1/OR2-1 (pseudogene)
Synonyms gene
- IGKVPZ1
- IGKV1OR-1
Synonyms gene name
- immunoglobulin kappa variable 1/OR-1
- immunoglobulin kappa variable 1/OR-1 pseudogene
- immunoglobulin kappa variable 1/OR-1 (pseudogene)
Synonyms
- IGKV1/OR-1
- IGKV1/OR2-1
GenBank acession
- Z12367
Locus

2p11.1
Discovery year

2000-04-18
Entrez gene record

3531
Pubmed identfication
- 2853098
Classification
- Immunoglobulin kappa (IGK) orphons
VEGA ID

OTTHUMG00000155081