PNU-74654

• Catalog number
  B1837-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydra-zide
• Description
  PNU-74654 is a β-catenin inhibitor (Kd = 450 nM), inhibiting its interaction with the transcription factor T cell factor 4 (Tcf4) resulting in disruption of the Wnt signaling pathway. Treatment of human adrenocortical cell lines with PNU-74654 significantly reduces expression of several Tcf/β-catenin target genes.
• CAS Number
  113906-27-7
• Structure Available
  Yes
• Molecular Formula
  C₁₉H₁₆N₂O₃
• Molecular Weight
  320.34
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>30 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A β-catenin inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  60119583
• PubChem CID Link
• SMILES
  CC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3
• InChi
  InChI=1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)
• InChi Key
  JJEDWBQZCRESJL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  PNU-74654  
• Short name
  PNU-74654
• Alternative name
  PNU-74654

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