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Anti-Axin1 (Polyclonal), ALEXA Fluor 594

Anti-Axin1 (Polyclonal), ALEXA Fluor 594 is available 1 time from Bioss polyclonal antibodies labs

GENTObs-2439R-A594 | Anti-Axin1 (Polyclonal), ALEXA Fluor 594 size: 100 microliters | 540.88 USD

Catalog number GENTObs-2439R-A594
Price 540.88 USD
Size 100 microliters
1. Gene info
Identity903
GeneAXIN1
Long gene nameaxin 1
Synonyms
GenBank acession
Locus16p13.3
Discovery year1998-09-17
Pubmed identfication
Havana BLAST/BLATOTTHUMG00000064930
MeSH Data
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    Lane 1: mouse heart probed with Rabbit Anti-Axin1 Polyclonal Antibody, Unconjugated (bs-2439R) at 1:300 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90 min at 37˚C.
Type Conjugated Primary Antibody
Conjugated with ALEXA FLUOR® 594
Host organism Rabbit (Oryctolagus cuniculus)
Target Protein/Peptide Axin1
Specificity This antibody reacts specifically with Axin1
Modification No modification has been applied to this antibody
Modification site None
Clonality Polyclonal Antibody
Clone Polyclonal Antibodies
Concentration 1ug per 1ul
Subcellular locations Cytoplasm, Nucleus
Antigen Source KLH conjugated synthetic peptide derived from human Axin1
Gene ID 8312
Swiss Prot O15169
Applications IF(IHC-P)
Applications with corresponding dilutions IF(IHC-P)(1:50-200)
Cross reactive species Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Cross Reactive Species details No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Background information Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Purification method Purified by Protein A.
Storage Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
Excitation emission 590nm/617nm
Synonyms AXIN; PPP1R49; Axin-1; Axis inhibition protein 1; hAxin; AXIN1
Also known as Axin1 Polyclonal Antibody
Other name Anti-Axin1 Polyclonal
Advisory Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
Properties For facs or microscopy Alexa 1 conjugate.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Group Polyclonals and antibodies
About Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
Gene targetAxin1
Short name Anti-Axin1 (Polyclonal)
Technique Polyclonal, anti
Label ALEXA FLUOR 594
Alternative name antibody to-axin 1 (polyclonal), ALEXA Fluor 594
Alternative technique polyclonals
Alternative to gene target axin 1, AXIN and PPP1R49, AXIN1 and IDBG-7404 and ENSG00000103126 and 8312, R-SMAD binding, nuclei, Axin1 and IDBG-154815 and ENSMUSG00000024182 and 12005, AXIN1 and IDBG-633677 and ENSBTAG00000016577 and 504357
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Anti-Axin1 (Polyclonal), ALEXA Fluor 594 size: 100 microlite
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