Conjugated Primary Antibody
ALEXA FLUOR® 594
Rabbit (Oryctolagus cuniculus)
This antibody reacts specifically with Axin1
No modification has been applied to this antibody
1ug per 1ul
KLH conjugated synthetic peptide derived from human Axin1
Applications with corresponding dilutions
Cross reactive species
Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
Cross Reactive Species details
No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
Purified by Protein A.
Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
AXIN; PPP1R49; Axin-1; Axis inhibition protein 1; hAxin; AXIN1
Also known as
Axin1 Polyclonal Antibody
Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
For facs or microscopy Alexa 1 conjugate.
Alexa Fluor,ALEXA FLUOR® 594
Alexa conjugate 1
This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Polyclonals and antibodies
Polyclonals can be used for Western blot, immunohistochemistry on frozen slices or parrafin fixed tissues. The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera.
ALEXA FLUOR 594
antibody to-axin 1 (polyclonal), ALEXA Fluor 594
Alternative to gene target
axin 1, AXIN and PPP1R49, AXIN1 and IDBG-7404 and ENSG00000103126 and 8312, R-SMAD binding, nuclei, Axin1 and IDBG-154815 and ENSMUSG00000024182 and 12005, AXIN1 and IDBG-633677 and ENSBTAG00000016577 and 504357
No similar products groups has been found