SIRT1 Inhibitor, EX-527

• Catalog number
  1652-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  EX-527, 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• Description
  A potent SIRT1 inhibitor (IC₅₀ = 38 nM). EX-527 is 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100µM. Enhances p53 acetylation in response to DNA damaging agents.
• CAS Number
  49843-98-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₃H₁₃ClN₂O
• Molecular Weight
  248.71
• Cell Permeable
  Yes
• Purity
  ≥97% by HPLC
• Solubilities
  DMSO (20 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A SIRT1 inhibitor
• Storage Condition
  +4°C
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD03009471
• PubChem CID
  5113032
• PubChem CID Link
• SMILES
  C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)Cl)C(=O)N
• InChi
  InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)
• InChi Key
  FUZYTVDVLBBXDL-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SIRT1   Inhibitor   EX-527  
• Gene symbol
  SIRT1-AS, SIRT1, MIR527
• Short name
  SIRT1 Inhibitor, EX-527
• Alternative name
  sirtuin 1 suppressor, EX-527
• Alternative to gene target
  sirtuin 1, SIR2L1, SIRT1 and IDBG-75847 and ENSG00000096717 and 23411, keratin filament binding, nuclei, Sirt1 and IDBG-159441 and ENSMUSG00000020063 and 93759, SIRT1 and IDBG-629119 and ENSBTAG00000014023 and 613629

Gene info

• Identity
  HGNC:51912
• Gene
  SIRT1-AS
• Long gene name
  SIRT1 antisense RNA
• Locus
  10q21.3
• Discovery year
  2015-09-23
• Entrez gene record
  106633813
• Pubmed identfication
  • 26324025
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:14929
• Gene
  SIRT1
• Long gene name
  sirtuin 1
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1
  • sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
• Synonyms
  • SIR2L1
• GenBank acession
  • AF083106
• Locus
  10q21.3
• Discovery year
  2001-03-20
• Entrez gene record
  23411
• Pubmed identfication
  • 10381378
• RefSeq identity
  • NM_012238
• Classification
  • eNoSC complex
  • Sirtuins
• VEGA ID
  OTTHUMG00000018340

Gene info

• Identity
  HGNC:32129
• Gene
  MIR527
• Long gene name
  microRNA 527
• Synonyms gene
  • MIRN527
• Synonyms
  • hsa-mir-527
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574497
• RefSeq identity
  • NR_030219
• Classification
  • MicroRNA MIR515 family

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